Results 81 to 90 of about 5,040,527 (296)

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

open access: yesFEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini   +3 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Mechanism of Mechanical Strengths for Corrugated Fiberboard.

open access: yesJAPAN TAPPI JOURNAL, 1994
Mechanism of mechanical strengths is discussed for corrugated fiberboards of single face, single wall and double wall. The strength under the tensile load is discussed by the experimental results of the tensile deformation. Their strengths under the surface compression and the uniform bending made from the applied moment of the axis along the machine ...
openaire   +2 more sources

Measurement Research of Motorized Spindle Dynamic Stiffness under High Speed Rotating

open access: yesShock and Vibration, 2015
High speed motorized spindle has become a key functional unit of high speed machine tools and effectively promotes the development of machine tool technology.
Xiaopeng Wang, Yuzhu Guo, Tianning Chen
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

A Novel Aerodynamic Force and Flutter of the High-Aspect-Ratio Cantilever Plate in Subsonic Flow

open access: yesShock and Vibration, 2020
This paper focuses on the derivation of the aerodynamic force for the cantilever plate in subsonic flow. For the first time, a new analytical expression of the quasi-steady aerodynamic force related to the velocity and the deformation for the high-aspect-
Li Ma   +5 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

Approximate Analytical Methodology for the Restricted Three-Body and Four-Body Models Based on Polynomial Series

open access: yesInternational Journal of Aerospace Engineering, 2016
The restricted three-body problem (R3BP) and restricted four-body problem (R4BP) are modeled based on the rotating frame. The conservative autonomous system for the R3BP and nonautonomous system with period parametric resonance due to the fourth body are
Ying-Jing Qian   +3 more
doaj   +1 more source

Mechanical properties of mesoporous ceria nanoarchitectures [PDF]

open access: yes, 2014
Architectural constructs are engineered to impart desirable mechanical properties facilitating bridges spanning a thousand meters and buildings nearly 1 km in height.
Parker, Stephen C.   +10 more
core   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

open access: yesMolecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan   +8 more
wiley   +1 more source

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