Results 161 to 170 of about 7,604,628 (414)

Modeling temperature and residual stress fields in selective laser melting

open access: yes, 2018
The paper investigates the temperature and residual stress fields in the selective laser melting (SLM) process. A three-dimensional thermo-mechanical coupling model is developed to simulate a multi-track multi-layer SLM process using the finite element ...
Shu Beng Tor   +11 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

The Effect of Different Bleaching Treatments and Thermal-Mechanical Cycling on the Shear Bond Strength of Orthodontic Brackets

open access: yesTurkish Journal of Orthodontics, 2018
Objective:The aim of the present study was to compare the shear bond strength (SBS) of orthodontic brackets bonded to the enamel after at-home and in-office bleaching treatments.Methods:Sixty bovine incisors were subjected to initial color readings and ...
Lilian Nascimento Carlos   +4 more
doaj   +1 more source

Mechanical stress and osteocyte RANKL

open access: yesProceedings for Annual Meeting of The Japanese Pharmacological Society, 2022
Takehito Ono
semanticscholar   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

The creep behavior of simple structures with a stress range-dependent constitutive model

open access: yes, 2012
High temperature design remains an issue for many components in a variety of industries. Although finite element analysis for creep is now an accessible tool, most analyses outside the research domain use long standing and very simple constitutive models
Boyle, James
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

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