Results 181 to 190 of about 536,244 (268)

Lung adenocarcinoma cells respond differently to mechanical stress in 3D versus 2D environments. [PDF]

Commun Biol
Kitamura N, Iwatake M, Mizoguchi S, Ibrahim Wani S, Kobayashi K, Hasnain M, Nguyen VD, Yokoyama R, Kitade N, Ojima T, Shimoyama K, Koba N, Hatta H, Raredon MSB, Hirabayashi K, Morinaga Y, Tsuchiya T.   +16 more
europepmc   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

In vivo mechano-tissue engineering by hydrogels capable of transmitting intercellular mechanical stress. [PDF]

Nat Commun
Ueda N, Okazaki H, Mikuma A, Kunieda A, Kawashima S, Torii T, Kawauchi K, Matsuoka M, Onodera T, Iwasaki N, Nagahama K.   +10 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Elucidating the underlying mechanism of mechanical stress-induced impact on mRNA-LNP structure. [PDF]

Sci Rep
Jensen EL, Chi YC, Edwards R, Wang HL, Matthessen R, Goffin B, Van Hees S, Friese OV, Van Pottelberge R.   +8 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

CCDC141 is a Connectin/Titin and Nesprin-1 binding protein that adapts cardiomyocytes to mechanical stress. [PDF]

Commun Biol
Hanashima A, Kimoto M, Ujihara Y, Hashimoto K, Usui Y, Ohira M, Hoshino M, Uesugi K, Witt S, Labeit D, Kimura S, Murayama T, Sakurai T, Labeit S, Mohri S.   +14 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Bridging the Gap: Small Airways, Mechanical Stress, and the Evolution of Emphysema. [PDF]

Am J Respir Crit Care Med
Han MK, Hatt C.
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source