Results 181 to 190 of about 7,604,628 (414)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Development of Primary Cell Cultures from Haplochromine Cichlid Bone-Derived Tissues

Fishes
Bone is a dynamic tissue with ecological and evolutionary importance, as it can grow and remodel itself in response to mechanical stimuli. In mammals, osteocytes are widely recognised as the central regulators of bone formation and mechanotransduction ...
Deepti Negi, Penelope M. Tsimbouri, Matthew J. Dalby, Kevin J. Parsons   +3 more
doaj   +1 more source

3D Hydro-mechanical Scenario Analysis to Evaluate Changes of the Recent Stress Field as a Result of Geological CO2 Storage

, 2013
Fabien Magri, Elena Tillner, Wenqing Wang, Norihiro Watanabe, Günter Zimmermann, Thomas Kempka   +5 more
openalex   +1 more source

Stress-induced anisotropic poroelasticity in Westerly granite: Mechanical and Ultrasonic data

, 2023
Bobby Elsigood, Nicolas Brantut, P. G. Meredith, T. M. Mitchell, David Healy   +4 more
openalex   +2 more sources

Depth-dependent stress-strain relation for friction prediction

, 2014
The effect of strain gradient on the mechanical property of a material is implemented through a depth-dependent stress strain relation model in conventional finite element simulations for use in friction prediction.
Castagne, Sylvie, Taureza, Muhammad, Song, Xu   +2 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Research progress on the role of biomechanical clues in the progression of lung cancer

Frontiers in Cell and Developmental Biology
Cells in mammals perceive and react to the mechanical properties of their surrounding environment. Disease progression is frequently linked to dynamic changes in cellular and tissue mechanics.
Fengying Gong, Fengying Gong, Qiang Zhang, Qin Fan, Rongmei Qu, Congrong Wang, Ting Yang, Tingyu Fan, Ying Lv, Jingxing Dai   +9 more
doaj   +1 more source

Identifying differential gene expression induced by mechanical stress in cartilage of human explants using RNA-sequencing [PDF]

, 2021
E. Houtman, Margo Tuerlings, Janne Riechelman, H. Eka D. Suchiman, Rob G. H. H. Nelissen, Y.F. Ramos, Rodrigo Coutinho de Almeida, Ingrid Meulenbelt   +7 more
openalex   +1 more source

Prediction and optimization of residual stresses, weld-bead profile and mechanical properties of laser welded components [PDF]

, 2006
Recently, laser welding has become a leading industrial joining process. Mainly because it has become highly automated using sophisticated robotic systems. However, to make effective use of automated laser welding it is essential to have a high degree of
Benyounis, Khaled
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source