Results 191 to 200 of about 536,244 (268)

Mechanical stress on the rod in posterior spinal fusion with and without rod fracture: a finite element analysis. [PDF]

BMC Musculoskelet Disord
Inoue T, Kumano Y, Sugaya J, Okazaki K, Doi T.   +4 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Loss of mechanical stress induces synovitis, fibrosis and articular cartilage degeneration via distinct synovial cell subsets. [PDF]

Sci Rep
Ishikura H, Okada H, Kin Y, Chijimatsu R, Higuchi J, Miyahara J, Tachibana N, Nagata K, Terashima A, Yano F, Omata Y, Seki M, Suzuki Y, Baron R, Tanaka S, Saito T.   +15 more
europepmc   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Impact of Abnormal Mechanical Stress on Chondrocyte Death in Osteoarthritis. [PDF]

Med Sci Monit
Du J, Sun X, Ao L, Zhou X, Shi H, Yong Q, Zhang X, Guan T.   +7 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Calcium waves and nuclear tension changes coordinate mechanical stress dissipation in locally folded epithelia. [PDF]

iScience
Brun-Cosme-Bruny M, Pernet L, Elias K, Guilluy C, Oddou C, Dolega ME.   +5 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Tissue scaffold architecture affects implant degradation and bone tissue regeneration: A novel in silico mechanobiological model analysing cell behavior, mechanical stress and degradation kinematics. [PDF]

PLoS One
Alshammari A, Alabdah F, Li L, Cooper G.
europepmc   +1 more source