Results 101 to 110 of about 1,690,858 (288)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Numerical Simulation Study on Welding Process of Upper Frame of Hydropower Unit

Applied Sciences
To optimize the welding process of the upper frame of the hydropower unit, a thermal elastic–plastic (TEP) finite element model of the typical T-joint of the upper frame was established, and the effectiveness and accuracy of the model were verified by ...
Chenlei Yu, Jun Pan, Junzhao Han, Jianfeng Ma, Weiliang Zhang   +4 more
doaj   +1 more source

Report of the sensor cooler technology panel [PDF]

, 1991
The Sensor Cooler Technology Panel identified three major areas in which technology development must be supported in order to meet the system performance requirements for the Astrotech 21 mission set science objectives. They are: long life vibration free
Castles, S., Gautier, N., Kittel, P., Ludwigsen, J., Ross, Ronald   +4 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Research on Skin Friction Drag Reduction by Vibrant Wall

Journal of Fluid Science and Technology, 2011
To reduce aerodynamic drag, reduction of skin friction is required. Vibrant flexible wall has been proposed to reduce skin friction drag for a long time. However, there are many problems for the flexible wall to get practical durability, easy maintenance
Kazuo YANAGIMOTO, Satoru YAMAMOTO, Naoki HAMAMOTO, Hiromitsu KAWAZOE   +3 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Fatigue Damage Assessment of Turbine Runner Blades Considering Sediment Wear

Applied Sciences
The wear phenomenon that occurs on the blades during operation has a significant impact on the fatigue life of the blades. To address the issue of fatigue life assessment for turbine runner blades subjected to increased dynamic stress due to sediment ...
Haifeng Chen, Jun Pan, Shuo Wang, Jianfeng Ma, Weiliang Zhang   +4 more
doaj   +1 more source

High-power baseline and motoring test results for the GPU-3 Stirling engine [PDF]

Test results are given for the full power range of the engine with both helium and hydrogen working fluids. Comparisons are made to previous testing using an alternator and resistance load bank to absorb the engine output.
Thieme, L. G.
core   +1 more source

Thermal behaviour of single ply triaxial woven fabric composites [PDF]

, 2010
This paper studies the complex thermal deformation of single-ply triaxial weave com- posites. This behaviour is studied experimentally, by testing ?at plates and narrow strips of TWF, and numerically, by carrying out ?nite-element simulations that ...
Kueh, A. B. H., Pellegrino, S.
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source