Mechanical testing of frontal plane adaptability of commercially available prosthetic feet. [PDF]
J Rehabil Assist Technol Eng, 2022 Wernke MM +6 more
europepmc +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Finite element analysis of mandibular fracture fixation authenticated by 3D printed mandible mechanical testing. [PDF]
Sci RepDaqiq O +5 more
europepmc +1 more source
Biomechanical duality of fracture healing captured using virtual mechanical testing and validated in ovine bones. [PDF]
Sci Rep, 2022 Inglis B +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Tuning and validation of a virtual mechanical testing pipeline for condylar stress fracture risk assessment in Thoroughbred racehorses. [PDF]
R Soc Open SciIrandoust S, Whitton C, Henak C, Muir P.
europepmc +1 more source
Mechanical testing of cephalomedullary nail lag screws after the addition of hydroxyapatite substitutes. [PDF]
OTA Int, 2021 Nakajima T +9 more
europepmc +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Flammability and Mechanical Testing of Sandwich Composite for Rolling Stock Structural Applications. [PDF]
Materials (Basel)Kalinowski M, Szczepanik M, Szymiczek M.
europepmc +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source