Results 181 to 190 of about 585,172 (311)

A Bayesian constitutive model selection framework for biaxial mechanical testing of planar soft tissues: Application to porcine aortic valves. [PDF]

J Mech Behav Biomed Mater, 2023
Aggarwal A, Hudson LT, Laurence DW, Lee CH, Pant S.   +4 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Real-time microdamage and strain detection during micromechanical testing of single trabeculae

, 2007
For the assessment of local deformations, we recently combined mechanical testing of trabecular bone with high-speed photography. In a previous study on cuboids of human vertebral trabecular bone we found strained trabeculae to whiten, and scanning ...
Hansma, Paul K., Schitter, Georg, Jungmann, Ralf, Fantner, Georg E., Thurner, Philipp J., Lauer, Matthias E.   +5 more
core  

Density-Based Topology-Optimized 3D-Printed Fixtures for Cyclic Mechanical Testing of Lattice Structures. [PDF]

Polymers (Basel)
Castro J, Valle R, Leiva J, Oñate A, Saggionetto E, Mertens A, Tuninetti V.   +6 more
europepmc   +1 more source

Vibrometry as a noncontact alternative to dynamic and viscoelastic mechanical testing in cartilage. [PDF]

J R Soc Interface, 2021
Espinosa MG, Otarola GA, Hu JC, Athanasiou KA.   +3 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

A Comprehensive Mechanical Testing of Polyacrylamide Hydrogels: The Impact of Crosslink Density. [PDF]

Polymers (Basel)
Antipova CG, Krupnin AE, Zakirov AR, Pobezhimov VV, Romanenko DA, Stolyarova DY, Chvalun SN, Grigoriev TE.   +7 more
europepmc   +1 more source

Comparative mechanical testing for different orthodontic aligner materials over time - in vitro study. [PDF]

J Clin Exp Dent, 2022
Nowak CM, Othman A, Ströbele DA, von See C.   +3 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Determination of wood strength properties through standard test procedures

, 2012
In this study a review of existing recognised standards for wood mechanical testing was conducted. This review considers tensile, compressive, bending and shear test methodologies from a range of sources.
Perera, Noel, Naylor, Andrew, Hackney, Philip   +2 more
core