Results 191 to 200 of about 1,715,737 (308)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Mitigation of image distortion during mechanical testing within a dynamic stereo x-ray system. [PDF]

Front Bioeng Biotechnol
Paglia DN, Chomack JM, Herlihy DV, Wetterstrand C, Kadkoy Y, Duchnycz R, Kelly P, O'Connor JP, D'Andrea SE, Maikos JT.   +9 more
europepmc   +1 more source

Robot and mechanical testing of a specialist manual toothbrush for cleaning efficacy and improved force control. [PDF]

BMC Oral Health, 2022
Acherkouk A, Götze M, Kiesow A, Ramakrishnan A, Sarembe S, Lang T, Gaengler P.   +6 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Rings in Taylor Spatial Frame: Mechanical testing and finite element analysis. [PDF]

Proc Inst Mech Eng H
Zamani A, Zenios M, Oyadiji SO.
europepmc   +1 more source

Mechanical testing of frontal plane adaptability of commercially available prosthetic feet. [PDF]

J Rehabil Assist Technol Eng, 2022
Wernke MM, Ficanha EM, Thomas Z, Maitland ME, Allyn KJ, Albury A, Colvin J.   +6 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Finite element analysis of mandibular fracture fixation authenticated by 3D printed mandible mechanical testing. [PDF]

Sci Rep
Daqiq O, van Minnen B, Spijkervet FKL, Wubs FW, Lunter G, Roossien CC.   +5 more
europepmc   +1 more source

Biomechanical duality of fracture healing captured using virtual mechanical testing and validated in ovine bones. [PDF]

Sci Rep, 2022
Inglis B, Schwarzenberg P, Klein K, von Rechenberg B, Darwiche S, Dailey HL.   +5 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source