Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Risk assessment for condylar stress fracture in elite racing Thoroughbreds using standing computed tomography-based virtual mechanical testing. [PDF]
Brown NL +5 more
europepmc +1 more source
Circular Production, Designing, and Mechanical Testing of Polypropylene-Based Reinforced Composite Materials: Statistical Analysis for Potential Automotive and Nuclear Applications. [PDF]
Hussain A +5 more
europepmc +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
The impact of pedicle screw transitional segment and thread distribution on postoperative rod-screw system failure : insights from clinical research and mechanical testing. [PDF]
Peng W +10 more
europepmc +1 more source
Mechanical testing data from neutron irradiations of PM-HIP and conventionally manufactured nuclear structural alloys. [PDF]
Wharry JP +10 more
europepmc +1 more source
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Effectiveness of spacecraft testing programs [PDF]
The need for testing under simulated mission operational conditions is discussed and the results of such tests are reviewed from the point of view of the user.
Krausz, A.
core +1 more source
The Mechanism and Interrelationships of the Flocculation Tests [PDF]
N F, MACLAGAN, N H, MARTIN, J B, LUNNON
openaire +2 more sources

