Organoids in pediatric cancer research
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Study of stress corrosion in aluminum alloys [PDF]
Mechanism of the stress corrosion cracking of high-strength aluminum alloys was investigated using electrochemical, mechanical, and electron microscopic techniques.
Brummer, S. B.
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Hastelloy X properties, data, and metallurgical characteristics [PDF]
Literature survey and testing program were initiated to obtain pertinent information for Hastelloy X, a nickel-base alloy, through the temperature range of minus 423 degrees to 1800 degrees F.
Glasier, L. F., Jr.
core +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Torque modeling of a novel magnetic coupler with multi-disk flux regulation via angular displacement: analytical FEM co-design [PDF]
This paper proposes a novel axially fixed multi-disk magnetic flux-regulatable magnetic coupler with modular topology, which addresses critical limitations such as the structural scalability of conventional magnetic couplers.
S. Zheng +5 more
doaj +1 more source
The processing and testing of aluminium matrix composite wires, double composites and block composites [PDF]
The Composite Processing and Testing Laboratory operated for about 15 years in USA. After that, in 2004- 2005, it moved from Boston to the Budapest University of Technology and Economics One of the main results from research and development projects is
Dobránszky, János +3 more
core
The Planck-LFI flight model composite waveguides [PDF]
The Low Frequency Instrument on board the PLANCK satellite is designed to give the most accurate map ever of the CMB anisotropy of the whole sky over a broad frequency band spanning 27 to 77 GHz.
A Mennella +32 more
core +3 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
In situ nanocompression testing of irradiated copper. [PDF]
Increasing demand for energy and reduction of carbon dioxide emissions has revived interest in nuclear energy. Designing materials for radiation environments necessitates a fundamental understanding of how radiation-induced defects alter mechanical ...
Hosemann, P +3 more
core +3 more sources

