Results 61 to 70 of about 1,697,500 (308)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

A Review on Application of Pin-Fins in Enhancing Heat Transfer

Energies
The pin-fin is one of the main technologies in enhancing heat transfer. The accelerated flow and vortex structures are produced, which can disrupt the development of the flow boundary layer.
Tao Yang, Xiaoming Zhang, Zhenyuan Chang, Ran Xu, Jiaojiao Ma, Liang Xu, Lei Xi   +6 more
doaj   +1 more source

Tunable Terahertz Plasmonic Sensor Based on Graphene/Insulator Stacks

IEEE Photonics Journal, 2017
We propose a layer-by-layer graphene/insulator stacks based terahertz plasmonic sensor of refractive index of testing samples using a prism-coupling attenuated total reflection configuration.
Yi Huang, Shuncong Zhong, Haizi Yao, Daxiang Cui   +3 more
doaj   +1 more source

Effects of hydrolysis ageing on the performance and dimensional stability of glass-fiber reinforced polyamide 66 [PDF]

, 2010
Results of an in-depth study of hydrolysis testing on the mechanical performance, weight change, and dimensional stability of injection moulded glass-fiber reinforced polyamide 66 automotive composites are presented. Composite and resin samples have been
Ali, Jahan Z., Anderson, John, Thomason, James L.   +2 more
core  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Polycaprolactone strengthening gelatin/nano-hydroxyapatite composite biomaterial inks for potential application in extrusion-based 3D printing bone scaffolds

Collagen and Leather
Extrusion-based three-dimensional (3D) printing of gelatin (Gel) is crucial for fabricating bone tissue engineering scaffolds via additive manufacturing.
Chenxin Wang, Mao Yang, Li Chen, Yijing Stehle, Mingyue Lin, Rui Zhang, Huanshuo Zhang, Jiehui Yang, Min Huang, Yubao Li, Qin Zou   +10 more
doaj   +1 more source

Validation of a laboratory method for evaluating dynamic properties of reconstructed equine racetrack surfaces. [PDF]

, 2012
BackgroundRacetrack surface is a risk factor for racehorse injuries and fatalities. Current research indicates that race surface mechanical properties may be influenced by material composition, moisture content, temperature, and maintenance. Race surface
Chau, Anh, Fyhrie, Patricia B, Hubbard, Mont, Setterbo, Jacob J, Stover, Susan M, Symons, Jennifer E, Upadhyaya, Shrini K   +6 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Spatiotemporal mapping of osteomyelitis pathogenesis guides the design of functionally graded bone regeneration scaffolds

Scientific Reports
Recurrent osteomyelitis remains a formidable challenge, with failure rates exceeding 25%. This study establishes a reproducible rabbit femoral model to systematically map the spatiotemporal pathogenesis of Staphylococcus aureus-induced osteomyelitis ...
Chenxin Wang, Li Chen, Yijing Stehle, Mingyue Lin, Rui Zhang, Huanshuo Zhang, Jiehui Yang, Denglang Hu, Mao Yang, Min Huang, Yubao Li, Qin Zou   +11 more
doaj   +1 more source

Testing Mechanisms

Economists are often interested in the mechanisms by which a treatment affects an outcome. We develop tests for the "sharp null of full mediation" that a treatment $D$ affects an outcome $Y$ only through a particular mechanism (or set of mechanisms) $M$.
Kwon, Soonwoo, Roth, Jonathan
openaire   +2 more sources