Results 61 to 70 of about 2,591,649 (241)

Remote Ischemic Post‐Conditioning Preserves the Neurovascular Unit by Brain‐Derived Gas6 That Drives Monocyte‐Derived Macrophage Reprogramming via Axl and Vimentin after SAH

Advanced Science, EarlyView.
Subarachnoid hemorrhage (SAH) triggers monocyte‐derived macrophage (MDM) infiltration and M1‐like polarization via Vimentin upregulation, leading to neurovascular unit disruption and cognitive dysfunction. Remote ischemic postconditioning (RIPostC) upregulates neuronal Gas6, which activates Axl on MDMs to downregulate Vimentin and drive reparative M2 ...
Yajun Zhu, Zichao Huang, Xi Rong, Xingwei Lei, Fuming Liang, Xiaoguo Li, Jiru Zhou, Yu Wang, Yifan Huang, Shuang Tang, Jianjun Zhong, Jin Yan, Hongji Deng, Chun Zeng, Zongduo Guo   +14 more
wiley   +1 more source

Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation

Advanced Science, EarlyView.
Mitochondrial transfer and transplantation (mitoTT) is examined as a multistep process governed by distinct transfer routes and post‐transfer checkpoints. Mechanisms controlling mitochondrial uptake, network integration, cristae remodeling, mtDNA maintenance, immune sensing, and quality control are highlighted, revealing key biological and ...
F. Seyma Gokdemir, Yagmur Ozendi, Gokhan Burcin Kubat, Keshav K. Singh   +3 more
wiley   +1 more source

Paradoxical pulmonary artery systolic pressure response with catheter-directed therapies for pulmonary embolism

American Heart Journal Plus, 2023
Background: Early data on use of catheter-directed therapies (CDT) for treatment of Intermediate or High-Risk pulmonary embolism (PE) show improvement in pulmonary artery systolic pressures (PAsP) and RV/LV ratios. Occasionally a paradoxical rise in PAsP
Patrick Ho, Farouk Al-Chami, Mara Caroline, Eric Gnall, Joseph Bonn, Lee Greenspon   +5 more
doaj   +1 more source

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke

Advanced Science, EarlyView.
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li, Pin‐yi Liu, Dan Wu, Fei‐yu Ma, Yi Bai, Sheng‐nan Xia, Hai‐yan Yang, Xin‐yu Bao, Yun Xu, Xiang Cao   +9 more
wiley   +1 more source

The Effectiveness and Safety of Mechanical Thrombectomy Compared with Thrombolytic Therapy in Acute Stroke: A Systematic Review and Meta-Analysis

Health Technology Assessment in Action, 2017
Background: This study aims to investigate the effectiveness of mechanical thrombectomy compared with thrombolytic therapy in patients with acute stroke.
Mojtaba Nouhi, Reza Jahangiri, Saber Azami, Mehrshad Azizi, Saman Ghasempour, Abdoreza Mousavi   +5 more
doaj   +1 more source

Stroke‐Heart Syndrome: Mechanisms, Temporal Phenotypes, and Diagnostic Reasoning

Advanced Science, EarlyView.
Stroke‐heart syndrome describes new or worsened cardiac abnormalities after acute stroke. This Review defines its clinical boundaries, traces autonomic, inflammatory, endothelial, and supply‐demand mechanisms across time, and proposes provisional phenotypes that integrate lesion location, premorbid cardiac substrate, serial biomarkers ...
Fa Lin, Jian Lyu, Yanci Liu, Zhiyuan Feng, Jie Bao, Wenxiong Song, Bingcheng Zhu, Minghao Liu, Jionghao Xue, Jiadi Weng, Jiani Zhang, Jizong Zhao, Xiaolin Chen, Bin Dong   +13 more
wiley   +1 more source

High White Blood Cell Count Is a Risk Factor for Contrast-Induced Nephropathy following Mechanical Thrombectomy for Acute Ischemic Stroke

Cerebrovascular Diseases Extra, 2020
Background: Although mechanical thrombectomy is a standard endovascular therapy for patients with acute ischemic stroke (AIS), the incidence of and risk factors for contrast-induced nephropathy (CIN) following mechanical thrombectomy are infrequently ...
Yuki Yamamoto, Nobuaki Yamamoto, Yasuhisa Kanematsu, Kazutaka Kuroda, Izumi Yamaguchi, Takeshi Miyamoto, Shu Sogabe, Kenji Shimada, Yasushi Takagi, Yuishin Izumi   +9 more
doaj   +1 more source

Impact of Laparoscopic Liver Resection on Long‐Term Outcomes and Non‐Liver‐Related Mortality in Elderly Patients With Primary Hepatocellular Carcinoma: A Multicenter Propensity Score‐Matched Analysis

Annals of Gastroenterological Surgery, EarlyView.
In this multicenter, propensity score–matched study of elderly patients with primary hepatocellular carcinoma, we compared long‐term cause‐specific mortality between laparoscopic (LLR) and open liver resection (OLR) using a competing‐risks framework. Among patients aged ≥ 80 years, LLR was associated with a lower 5‐year cumulative incidence of death ...
Yukio Tokumitsu, Hidenori Takahashi, Yuki Nakagami, Toru Hisaka, Hiromitsu Hayashi, Tomoharu Yoshizumi, Norifumi Harimoto, Takao Ide, Yoichi Yamasaki, Atsushi Miyoshi, Yuichi Endo, Tamotsu Kuroki, Atsushi Nanashima, Masahiko Sakoda, Tohru Utsunomiya, Kohji Okamoto, Masatoshi Kajiwara, Mitsuhisa Takatsuki, Toru Beppu, Susumu Eguchi   +19 more
wiley   +1 more source

Animal stroke models and outcome evaluation: A review

Animal Models and Experimental Medicine, EarlyView.
Rodents are the preeminent stroke model species. Large animal models exist too, but are poorly standardized. Ischemic and hemorrhagic experimental models are available, with the intraluminal filament model being predominant. Outcomes are evaluated via quantifying subjects' sensorimotor impairment, cognitive memory faculties, degree of cellular ...
Solsa Cariba, Helen M. Atkinson, Anthony K. C. Chan   +2 more
wiley   +1 more source

Updates in Mechanical Thrombectomy

, 2016
Strokes are a major source of morbidity and mortality worldwide. The long-standing gold standard in stroke therapy, intravenous administration of tissue plasminogen activator (tPA), is limited by strict timing parameters and modest efficacy in large strokes caused by thrombi in the proximal cerebral vasculature.
Robert C. Rennert, Arvin R. Wali, Christine Carico, Jeffrey Scott Pannell, Alexander A. Khalessi   +4 more
openaire   +2 more sources