Results 71 to 80 of about 2,429,653 (258)

Mechanical thrombectomy for large vessel occlusion strokes beyond 24 hours

open access: yes, 2023
Background Recent clinical trials have shown that mechanical thrombectomy is superior to medical management for large vessel occlusion for up to 24 hours from onset.
Bass, Eric   +10 more
core   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

open access: yesAdvanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen   +7 more
wiley   +1 more source

Closing the gap: Early experience from a new Endovascular Thrombectomy service in regional and rural North Queensland, Australia

open access: yesJournal of Stroke and Cerebrovascular Diseases
Background: Endovascular clot retrieval is the standard of care for acute ischemic stroke caused by large vessel occlusion. However, access to mechanical thrombectomy remains limited in rural and regional areas, where patients often require transfer to ...
Muhammad Usman Manzoor   +9 more
doaj   +1 more source

Intra-Arterial Mechanical Thrombectomy: An Effective Treatment for Ischemic Stroke Caused by Endocarditis

open access: yesCase Reports in Neurology, 2016
Patients with stroke secondary to infectious endocarditis have a high in-hospital morbidity and mortality, with only one-third becoming functionally independent.
Olafur Sveinsson   +2 more
doaj   +1 more source

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

open access: yesAdvanced Science, EarlyView.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang   +4 more
wiley   +1 more source

Mechanical Thrombectomy for Stroke After Cardiac Surgery

open access: yes, 2016
Stroke after cardiac surgery remains a devastating complication and its treatment options are limited. Systemic fibrinolysis is a relative contraindication, because it raises the risk of systemic hemorrhage. Endovascular therapy, mechanical thrombectomy,
Madeira, M   +5 more
core   +1 more source

Animal stroke models and outcome evaluation: A review

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Rodents are the preeminent stroke model species. Large animal models exist too, but are poorly standardized. Ischemic and hemorrhagic experimental models are available, with the intraluminal filament model being predominant. Outcomes are evaluated via quantifying subjects' sensorimotor impairment, cognitive memory faculties, degree of cellular ...
Solsa Cariba   +2 more
wiley   +1 more source

Mechanical Thrombectomy Versus Medical Management for Large Ischemic Core Stroke Identified before Inter‐Hospital Transfer: A Post Hoc Analysis of the LASTE Trial

open access: yesAnnals of Neurology, EarlyView.
Objective This study assessed the efficacy of thrombectomy in acute ischemic stroke because of large‐vessel occlusion (AIS‐LVO) initially admitted to primary stroke centers (PSC) and subsequently transferred to a comprehensive stroke center (CSC), with a large ischemic core identified before transfer.
Pierre Seners   +258 more
wiley   +1 more source

Comparison of Intracranial Hemorrhage and Clinical Outcomes Among Patients Undergoing Mechanical Thrombectomy with and without Thrombolytic Therapy [PDF]

open access: yes
Aim: It remains controversial whether intravenous tissue plasminogen activator (IV tPA) increases complications in patients undergoing mechanical thrombolysis. In this study, we aimed to show the effect of IV tPA administration on complications. Methods:
Zulfikar Memis, Irem Kuru
core   +1 more source

Percutaneous Transaxillary Access for Large‐Bore Cardiovascular Interventions: Evidence, Technique, and Complication Management

open access: yesCatheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Percutaneous transaxillary access is an established alternative to transfemoral large‐bore arterial access for transcatheter structural heart interventions and mechanical circulatory support (MCS). Although useful for overcoming hostile iliofemoral anatomy and providing prolonged support and patient mobilization in case of MCS, the axillary ...
Gioel Gabrio Secco   +9 more
wiley   +1 more source

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