Results 41 to 50 of about 2,529,407 (323)

Accuracy of ventilator-associated events for the diagnosis of ventilator-associated lower respiratory tract infections

Annals of Intensive Care, 2020
Background The aim of this study was to investigate the concordance between ventilator-associated events (VAE) and ventilator-associated lower respiratory tract infections (VA-LRTI), and their impact on outcome.
Olivier Pouly, Sylvain Lecailtel, Sophie Six, Sébastien Préau, Frédéric Wallet, Saad Nseir, Anahita Rouzé   +6 more
doaj   +1 more source

Alveolar mechanics: A new concept in respiratory monitoring

Journal of Mechanical Ventilation, 2022
A detailed understanding of respiratory mechanics during mechanical ventilation aids diagnostic accuracy and facilitates close monitoring of patient progress, allowing individualized ventilator adjustments aimed at minimizing ventilator induced lung ...
Ehab G. Daoud, Claudio Luciano Franck
doaj   +1 more source

The mechanics of mechanical ventilation [PDF]

Revista Médica de Minas Gerais, 2014
The Ventilator has represented an advance in the respiratory support for patients on anesthesia and intensive care. The ventilatory support increases the chance of survival in patients with respiratory failure, and / or major surgical procedures. This paper consists of a summary of advances in the ventilatory support, in describing the physiological ...
Renan Murta Soares de Almeida, Aline Siqueira Melo, Cláudio Dornas de Oliveira   +2 more
openaire   +1 more source

Design and performance testing of a novel emergency ventilator for in-hospital use

Canadian Journal of Respiratory Therapy, 2020
Background The rapidly evolving COVID-19 pandemic has led to increased use of critical care resources, particularly mechanical ventilators. Amidst growing concerns that the health care system could face a shortage of ventilators in the future, there is ...
Knorr Jacob M., Sheehan Megan M., Santana Daniel C., Samorezov Sergey, Sammour Ibrahim, Deblock Michael, Kuban Barry, Chaisson Neal, Chatburn Robert L.   +8 more
doaj   +1 more source

Monitoring and Interpretation of Mechanical Ventilator Waveform in the Neuro-Intensive Care Unit [PDF]

Journal of Neurocritical Care, 2018
Management of mechanical ventilation is essential for patients with neuro-critical illnesses who may also have impairment of airways, lungs, respiratory muscles, and respiratory drive.
Jin Park
doaj   +1 more source

A Survey of Mechanical Ventilator Practices Across Burn Centers in North America

Journal of Burn Care & Research, 2016
Burn injury introduces unique clinical challenges that make it difficult to extrapolate mechanical ventilator (MV) practices designed for the management of general critical care patients to the burn population.
K. Chung, Ryan Y. Rhie, J. Lundy, R. Cartotto, E. Henderson, M. Pressman, Victor Joe, J. Aden, I. Driscoll, L. Faucher, R. Mcdermid, R. Mlcak, W. Hickerson, J. Jeng   +13 more
semanticscholar   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Simple Ventilators for Emergency Use Based on Bag-Valve Pressing Systems: Lessons Learned and Future Steps

Applied Sciences, 2020
As part of a plethora of global efforts to minimize the negative effects of the SARS-CoV2 (COVID-19) pandemic, we developed two different mechanisms that, after further development, could potentially be of use in the future in order to increase the ...
Enrique Castro-Camus, Jan Ornik, Cornelius Mach, Goretti Hernandez-Cardoso, Bhushan Savalia, Jochen Taiber, Armando Ruiz-Marquez, Karl Kesper, Srumika Konde, Caroline Sommer, Julian Wiener, David Geisel, Franziska Hüppe, Gunter Kräling, Peter Mross, Johnny Nguyen, Thomas Wiesmann, Björn Beutel, Martin Koch   +18 more
doaj   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source