Results 51 to 60 of about 80,331 (298)

Mechanical ventilation of mice [PDF]

Basic Research in Cardiology, 2000
Due to growing interest in murine functional genomics research, there is an increasing need for physiological stable in vivo murine models. Of special importance is support and control of ventilation by artificial respiration, which is difficult to execute as a consequence of the small size of the animal and the technically demanding breathing pattern.
Schwarte, L. A., Zuurbier, C. J., Ince, C.   +2 more
openaire   +4 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Monitoring and Interpretation of Mechanical Ventilator Waveform in the Neuro-Intensive Care Unit [PDF]

Journal of Neurocritical Care, 2018
Management of mechanical ventilation is essential for patients with neuro-critical illnesses who may also have impairment of airways, lungs, respiratory muscles, and respiratory drive.
Jin Park
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Patient-ventilator synchrony and tidal volume variability using NAVA and pressure support mechanical ventilation modes [PDF]

, 2011
peer reviewedNeurally Adjusted Ventilatory Assist (NAVA) is a new ventilatory mode in which ventilator settings are adjusted based on the electrical activity detected in the diaphragm (Eadi).
Moorhead, K. T., Piquilloud, L., Desaive, T., Bialais, E., Roeseler, J., Tassaux, D., Moorhead, K.T., Didier Tassaux, Chase, J. G., Bernard Lambermont, J. Geoffrey Chase, Katherine T. Moorhead, Philippe Jolliet, Thomas Desaive, Vignaux, L., Jolliet, P., Laurence Vignaux, Desaive, Thomas, LAMBERMONT, Bernard, Chase, Geoff, Lise Piquilloud, Jean Roeseler, Lambermont, B., Emilie Bialais   +23 more
core   +1 more source

Automated mechanical ventilation using Adaptive Support Ventilation versus conventional ventilation including ventilator length of stay, mortality, and professional social aspects of adoption of new technology

Journal of Mechanical Ventilation, 2021
Background Automation of mechanical ventilation allows for reduction of variation in patient management and has the potential to provide increased patient safety by strict adherence to computer driven ventilator protocols.
Ronald R. Sanderson, Denise Whitley, Christopher Batacan   +2 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Volatile diagnostic techniques for ventilator associated pneumonia [PDF]

, 2010
Ventilator associated pneumonia (VAP) is a significant challenge for the Intensive Care doctors worldwide. It is both difficult to diagnose accurately and quickly and to treat effectively once the diagnosis has been established.
Humphreys, Martyn Lee
core  

Stress-state-dependent constitutive model and fracture criterion of annealed 6056 aluminum alloy

AIP Advances
The high strength and formability of heat-treated 6056 aluminum alloys offer great potential for use in automotive components. To investigate the mechanical properties of annealed 6056 aluminum alloy, tensile tests were conducted on both standard and ...
Qingsen Hou, Naichang Chen, Zhiqiang Luo, Zonglian Wang   +3 more
doaj   +1 more source