Results 71 to 80 of about 516,257 (296)

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Mechanisms and mechanics of auditory masking

The Journal of Physiology, 2013
It is rare to hear just one sound at a time. More often than not, our experience of listening to someone speak, or hearing a piece of music, is made more challenging, and possibly more annoying, by the presence of interfering sound, be it traffic noise, air-conditioning rumble, or other people talking at the same time. In extreme situations, such as in
openaire   +4 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Geometric and Material Variability Influences Stress States Relevant to Coastal Permafrost Bluff Failure

Frontiers in Earth Science, 2020
Scientific knowledge and engineering tools for predicting coastal erosion are largely confined to temperate climate zones that are dominated by non-cohesive sediments. The pattern of erosion exhibited by the ice-bonded permafrost bluffs in Arctic Alaska,
Matthew A. Thomas, Alejandro Mota, Benjamin M. Jones, R. Charles Choens, Jennifer M. Frederick, Diana L. Bull   +5 more
doaj   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Mechanics, Molecular Physics and Heat [PDF]

, 1903
W. L. Stevens
openalex   +3 more sources

Upper limb movement control strategy of top-tier elite male badminton players when smashing for different distances

Human Movement
Purpose Mastering the skill of smashing in a game can be quite challenging. Unfortunately, it’s not always easy to control the distance of the smash. The present study investigated the impact of different smashing distances on muscle activation patterns ...
Tengfei Dong, Youngsuk Kim, Jungsuk Seo, Dong Moon Kim, Sukwon Kim   +4 more
doaj   +1 more source

Research on the Corrosion/Permeability/Frost Resistance of Concrete by Experimental and Microscopic Mechanisms Under Different Water–Binder Ratios

International Journal of Concrete Structures and Materials, 2020
To study the influence of different water–binder ratios on the corrosion, permeability, and freezing properties of concrete, we produced different strengths of concrete with respective water–binder ratios of 0.32, 0.38, 0.50, and 0.66.
Rongling Zhang, Peng Liu, Lina Ma, Zijiang Yang, Huisu Chen, Han Xing Zhu, Huigang Xiao, Jia Li   +7 more
doaj   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source