Results 81 to 90 of about 2,612,438 (358)

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

A utilização da filmadora digital para o estudo do movimento dos corpos

Revista Brasileira de Ensino de Física
Através de uma filmadora digital e do software de domínio público VirtualDub consegue-se registrar espacial e temporalmente a evolução dinâmica de um sistema muito rápido, como por exemplo, a queda livre.
B.N. Sismanoglu, J.S.E. Germano, J. Amorim, R. Caetano   +3 more
doaj   +1 more source

Job Opening for Nucleosome Mechanic: Flexibility Required

Cells, 2020
The nucleus has been studied for well over 100 years, and chromatin has been the intense focus of experiments for decades. In this review, we focus on an understudied aspect of chromatin biology, namely the chromatin fiber polymer’s mechanical ...
Mary Pitman, Daniël P. Melters, Yamini Dalal   +2 more
doaj   +1 more source

A Process Model of Quantum Mechanics

, 2014
A process model of quantum mechanics utilizes a combinatorial game to generate a discrete and finite causal space upon which can be defined a self-consistent quantum mechanics.
Sulis, William
core   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Cost-Efficient Open Source Desktop Size Radial Stretching System With Force Sensor

IEEE Access, 2015
The rapid and efficient development of soft active materials requires readily available, compact testing equipment. We propose a desktop-sized, cost-efficient, and open source radial stretching system as an alternative to commercially available biaxial ...
Stefan E. Schausberger, Rainer Kaltseis, Michael Drack, Umut D. Cakmak, Zoltan Major, Siegfried Bauer   +5 more
doaj   +1 more source

Interactive simulations for the learning and teaching of quantum mechanics concepts [PDF]

, 2014
Since 2009, we have been developing and evaluating interactive simulations with accompanying activities for the learning and teaching of quantum mechanics concepts at university level.
Kohnle, Antje
core  

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Mechanisms of embodiment [PDF]

Frontiers in Psychology, 2015
This paper is a critical review of recent studies demonstrating the mechanism of sensorimotor simulation in different cognitive domains. Empirical studies that specify conditions under which embodiment occurs in different domains will be discussed and evaluated.
Lysanne S. Post, Katinka Dijkstra
openaire   +4 more sources