Results 91 to 100 of about 275,739 (300)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Mechanics of materials. an introduction to the mechanics of elastic and plastic deformation of solids and structural materials /

, 1997
One of the most important subjects for any student of engineering or materials to master is the behaviour of materials and structures under load. The way in which they react to applied forces, the deflections resulting and the stresses and strains set up
Hearn, E. J.(Edwin John)
core  

Special issue of computational mechanics on machine learning theories, modeling, and applications to computational materials science, additive manufacturing, mechanics of materials, design and optimization. [PDF]

Comput Mech, 2023
Liu WK, Bessa MA, Chinesta F, Li S, Trask N.   +4 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Comparative Study of Two Aging Treatments on Microstructure and Mechanical Properties of an Ultra-Fine Grained Mg-10Y-6Gd-1.5Zn-0.5Zr Alloy

Metals, 2018
Developing high strength and high ductility magnesium alloys is an important issue for weight-reduction applications. In this work, we explored the feasibility of manipulating nanosized precipitates on LPSO-contained (long period stacking ordered phase ...
Huan Liu, He Huang, Ce Wang, Jia Ju, Jiapeng Sun, Yuna Wu, Jinghua Jiang, Aibin Ma   +7 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Fracture Mechanics Investigation of Structures with Defects

, 2013
Fracture mechanics plays an important role in the material science, structure design and industrial production due to the failure of materials and structures are paid high attention in human activities.
Li, Yong <1985>
core   +1 more source

Micro-mechanical modelling of high cycle fatigue behaviour of metals under multiaxial loads [PDF]

, 2012
An analysis of high cycle multiaxial fatigue behaviour is conducted through the numerical simulation of polycrystalline aggregates using the finite elementmethod.
PALIN-LUC, Thierry, MOREL, Franck, SAINTIER, Nicolas, ROBERT, Camille   +3 more
core   +1 more source

Comparative Study of the Tribological Performance of Hardox 400 Treated by PVD and Duplex Processes [PDF]

MATEC Web of Conferences
This study evaluates the tribological performance of CrN coatings deposited by PVD and a duplex treatment (carburizing followed by CrN deposition) applied to Hardox 400 steel.
Khaldi Abir, Ghanem AbdelKarim, Terres Mohamed Ali   +2 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source