Results 41 to 50 of about 216,200 (251)

Biodegradable Behaviors of Ultrafine-Grained ZE41A Magnesium Alloy in DMEM Solution

open access: yesMetals, 2015
The main limitation to the clinical application of magnesium alloys is their too-fast degradation rate in the physiological environment. Bio-corrosion behaviors of the ZE41A magnesium alloy processed by multi-pass equal channel angular pressing (ECAP ...
Jinghua Jiang   +6 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Stress Corrosion Cracking Behavior of Fine-Grained AZ61 Magnesium Alloys Processed by Equal-Channel Angular Pressing

open access: yesMetals, 2017
The effect of equal-channel angular pressing (ECAP) on stress corrosion cracking (SCC) behavior of a cast AZ61 Mg alloy was investigated in distilled water (DW) using the slow strain rate tensile test (SSRT) at a strain rate of 1 × 10−6 s−1.
Qiuyuan Xie   +6 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Solving nonlinear third-order three-point boundary value problems by boundary shape functions methods

open access: yesAdvances in Difference Equations, 2021
For nonlinear third-order three-point boundary value problems (BVPs), we develop two algorithms to find solutions, which automatically satisfy the specified three-point boundary conditions.
Ji Lin, Yuhui Zhang, Chein-Shan Liu
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Grain Refinement and High-Performance of Equal-Channel Angular Pressed Cu-Mg Alloy for Electrical Contact Wire

open access: yesMetals, 2014
Multi-pass equal-channel angular pressing (EACP) was applied to produce ultrafine-grained (UFG) Cu-0.2wt%Mg alloy contact wire with high mechanical/electric performance, aim to overcome the catenary barrier of high-speed trains by maximizing the tension ...
Aibin Ma   +6 more
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

General Multi-Fidelity Framework for Training Artificial Neural Networks With Computational Models

open access: yesFrontiers in Materials, 2019
Training of artificial neural networks (ANNs) relies on the availability of training data. If ANNs have to be trained to predict or control the behavior of complex physical systems, often not enough real-word training data are available, for example ...
Roland Can Aydin   +3 more
doaj   +1 more source

Damage Modelling of Compressed Earth Blocks Stabilised with Cement

open access: yesAdvances in Civil Engineering, 2022
This work aims at studying the mechanical behaviour of compressed Earth blocks (CEBs) and compressed stabilised Earth blocks (CSEBs) with 4% and 8% in weight cement stabilisation.
Janvier Goutsaya   +2 more
doaj   +1 more source

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