Results 51 to 60 of about 955,420 (292)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Dealloying-based interpenetrating-phase nanocomposites matching the elastic behavior of human bone
Scientific Reports, 2017 The long-term performance of orthopedic implants depends crucially on a close match between the mechanical behavior of bone and of the implant material. Yet, the present man-made materials with the required biocompatibility and strength are substantially
I. V. Okulov +2 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
On the impact of capillarity for strength at the nanoscale
Nature Communications, 2017 Nanoscale crystals can experience lattice instability and a tension-compression asymmetry of their strength. Here, Mameka and colleagues scrutinize the proposition that these phenomena arise from surface-induced stress, finding that the surface tension ...
Nadiia Mameka +2 more
doaj +1 more source
Metals, 2016 A commercial AZ91D Mg alloy, after bulk grain refinement by various passes of equal-channel angular pressing (ECAP), was selected for micro-arc oxidation (MAO) in silicate electrolyte, corrosion testing in 3.5 wt % NaCl solution and morphology analyses ...
Aibin Ma +6 more
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Science and Technology of Advanced MaterialsHydrogels are flexible materials that typically accommodate elongation with positive Poisson’s ratios. Auxetic property, i.e., the negative Poisson’s ratio, of elastic materials can be macroscopically implemented by the structural design of the continuum.
Daisuke Nakagawa, Itsuo Hanasaki
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Biodegradable Behaviors of Ultrafine-Grained ZE41A Magnesium Alloy in DMEM Solution
Metals, 2015 The main limitation to the clinical application of magnesium alloys is their too-fast degradation rate in the physiological environment. Bio-corrosion behaviors of the ZE41A magnesium alloy processed by multi-pass equal channel angular pressing (ECAP ...
Jinghua Jiang +6 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Metals, 2017 The effect of equal-channel angular pressing (ECAP) on stress corrosion cracking (SCC) behavior of a cast AZ61 Mg alloy was investigated in distilled water (DW) using the slow strain rate tensile test (SSRT) at a strain rate of 1 × 10−6 s−1.
Qiuyuan Xie +6 more
doaj +1 more source