Results 51 to 60 of about 27,391 (258)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Mechanisms of proton spin dephasing in a system of magnetic particles [PDF]
Magnetic Resonance in Medicine, 2011 AbstractFor protons diffusing among a system of magnetic particles, the process by which initial phase coherence is lost depends substantially on particle size. In this article, evidence for three dephasing mechanisms is presented: an incremental process at small particle sizes (motional averaging regime), a discrete process at intermediate particle ...
openaire +2 more sources
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
On Ontological Alternatives to Bohmian Mechanics
Entropy, 2018 The article describes an interpretation of the mathematical formalism of standard quantum mechanics in terms of relations. In particular, the wave function ψ(x) is interpreted as a complex-valued relation between an entity (often called &ldquo ...
Thomas Filk
doaj +1 more source
Statistical mechanics and the physics of many-particle model systems [PDF]
Physics of Particles and Nuclei, 2009 77 pages, 1 figure, Refs ...
openaire +2 more sources
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Cooling the motion of a silica microsphere in a magneto-gravitational trap in ultra-high vacuum
New Journal of Physics, 2018 Levitated optomechanical systems, and particularly particles trapped in vacuum, provide unique platforms for studying the mechanical behavior of objects well-isolated from their environment.
Bradley R Slezak +3 more
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Past of a quantum particle: old problem with recent controversies
Zagadnienia Filozoficzne w Nauce, 2022 Time-symmetric formulation of quantum mechanics—the two-state vector formalism—is presented as a tool for studying past behaviour of quantum systems. A role of weak measurement and weak values in the Cheshire Cat effect and a nested (Vaidman) three-path ...
Jerzy Dajka
doaj