Results 61 to 70 of about 31,014 (344)

Is There a Unique Physical Entropy? Micro versus Macro [PDF]

, 2012
Entropy in thermodynamics is an extensive quantity, whereas standard methods in statistical mechanics give rise to a non-extensive expression for the entropy. This discrepancy is often seen as a sign that basic formulas of statistical mechanics should be
Dieks, D.G.B.J., History and Foundations of Science, Dieks, Dennis, Sub Foundations&PhilosophyofNaturSc begr, Andersen, Hanne   +4 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Classical Mechanics Is Lagrangian; It Is Not Hamiltonian; The Semantics of Physical Theory Is Not Semantical [PDF]

, 2008
One can (for the most part) formulate a model of a classical system in either the Lagrangian or the Hamiltonian framework. Though it is often thought that those two formulations are equivalent in all important ways, this is not true: the underlying ...
Curiel, Erik, Erik Curiel
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Mechanical Properties of Dust, Pebbles, and Planetesimals Based on Johnson–Kendall–Roberts, Griffith, and Weibull Theories

The Astrophysical Journal
Mechanical properties of small bodies such as dust, pebbles, and planetesimals are key to better understanding the formation of planetary systems against their collisional destruction.
Hiroshi Kimura, Takaya Okamoto, Takayuki Hirai, Fumi Yoshida, Peng K. Hong, Koji Wada, Tomoko Arai, Eiichiro Kokubo, Yuki Yoshida, Toshihiko Kadono, Sota Arakawa, Hiroki Senshu, Masanori Kobayashi, Ko Ishibashi, Manabu Yamada, Hiroshi Akitaya, Osamu Okudaira, Takafumi Matsui   +17 more
doaj   +1 more source

Canonical Forms and Their Integrability for Systems of Three 2nd-Order ODEs

Advances in Mathematical Physics, 2017
Differential invariants and their corresponding canonical forms for systems of three 2nd-order ODEs possessing three-dimensional Lie algebras are constructed. Their extension up to kth-order system of three 2nd-order ODEs is presented.
S. Zahida, M. N. Qureshi, Muhammad Ayub
doaj   +1 more source

Linear Hamiltonian behaviors and bilinear differential forms [PDF]

, 2004
We study linear Hamiltonian systems using bilinear and quadratic differential forms. Such a representation-free approach allows us to use the same concepts and techniques to deal with systems isolated from their environment and with systems subject to ...
Rapisarda, P., Trentelman, H.L., Trentelman, H.L.,, Rapisarda, P, Rapisarda, P.,, Trentelman, HL, Rapisarda, Paolo, Trentelman, Harry L.   +7 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

PHYSICS: WHAT DOES ONE NEED TO KNOW?

Zygon, 1996
. For the basic areas of physics‐classical mechanics, classical field theories, and quantum mechanics‐there are local dynamical theories that offer complete descriptions of systems when the proper subsidiary conditions also are provided.
doaj   +2 more sources