Results 121 to 130 of about 11,555,627 (307)

Generalized Competing Glauber-type Dynamics and Kawasaki-type Dynamics

, 2002
In this article, we have given a systematic formulation of the new generalized competing mechanism: the Glauber-type single-spin transition mechanism, with probability p, simulates the contact of the system with the heat bath, and the Kawasaki-type spin ...
Attila Szolnoki, B.C.S. Grandi, B.C.S. Grandi, B.C.S. Grandi, B.C.S. Grandi, B.C.S. Grandi, Han Zhu, Han Zhu, Jian-yang Zhu, Jian-Yang Zhu, Jian-Yang Zhu, Jian-Yang Zhu, K. Kawasaki, Ma Yuqiang, Mauricio Godoy, R.J. Glauber, S. Bekhechi, T. Tome, Yang Zhou, Yu-qiang Ma   +19 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

The Core-Collapse Supernova Explosion Mechanism

, 2016
The explosion mechanism of core-collapse supernovae is a long-standing problem in stellar astrophysics. We briefly outline the main contenders for a solution and review recent efforts to model core-collapse supernova explosions by means of multi ...
Müller, B.
core   +1 more source

Mechanisms

Deutsches Ärzteblatt international, 2021
openaire   +3 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Efficacy and safety of low-dose interleukin 2 for Behçet’s syndrome: a randomized, placebo-controlled, double-blind, phase 2 clinical trial

Nature Communications
Behçet’s syndrome (BS), a chronic vasculitis, leads to recurrent oral ulcers, severely impacting quality of life. Here we report the results of a randomized, double-blind, placebo-controlled trial (NCT04065672) to evaluate the efficacy and safety of low ...
Tian Liu, Wenyan Zhou, Yan Zhu, Weiyi Xia, Jiali Chen, Xian Xiao, Bo Huang, Ruiling Feng, Hua Ye, Shi Chen, Xiaoying Zhang, Miao Shao, Chun Li, Yuan Jia, Miao Miao, Yuebo Jin, Xue Li, Xia Zhang, Yunshan Zhou, Ru Li, Xuewu Zhang, Yin Su, Huixin Liu, Jing Li, Fanlei Hu, Jianping Guo, Xiaolin Sun, Jing He, Zhanguo Li   +28 more
doaj   +1 more source

Towards a new crown indicator: Some theoretical considerations [PDF]

, 2010
The crown indicator is a well-known bibliometric indicator of research performance developed by our institute. The indicator aims to normalize citation counts for differences among fields.
van Eck, Nees Jan, van Leeuwen, Thed N., van Raan, Anthony F. J., Visser, Martijn S., Waltman, Ludo   +4 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Theoretical understanding and technical practice of shale oil development in continental faulted basins in eastern China： A case study of Jiyang shale oil

Youqi dizhi yu caishoulu
The shale oil in the continental faulted basins in eastern China，represented by Jiyang shale oil，has made a breakthrough in production capacity. However，Jiyang shale oil faces great challenges in achieving high and stable production due to the large ...
YANG Yong, ZHANG Shiming, LÜ Qi, SUN Zhigang, JIANG Long, SUN Hongxia, LIU Zupeng, LÜ Jing, XING Xiangdong, NI Liangtian   +9 more
doaj   +1 more source