Results 101 to 110 of about 2,563,992 (349)

Effect of ergothioneine on tissue metabolism in middle-aged and aged mice [PDF]

Jichu yixue yu linchuang
Objective To investigate the effect of ergothioneine(EGT) on tissue metabolism in middle-aged and aged mice. Methods Nine-month-old middle-aged and aged C57BL/6J mice were selected to be gavaged with EGT aqueous solution at the dose and frequency of 35 ...
CHEN Haoran, WANG Fang, MA Yanni, YU Jia, WANG Lin
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Proteome and ubiquitinome analyses of the brain cortex in K18-hACE2 mice infected with SARS-CoV-2

iScience
Summary: Clinical research indicates that SARS-CoV-2 infection is linked to several neurological consequences, and the virus is still spreading despite the availability of vaccinations and antiviral medications. To determine how hosts respond to SARS-CoV-
Qiaochu Wang, Wanjun Peng, Yehong Yang, Yue Wu, Rong Han, Tao Ding, Xutong Zhang, Jiangning Liu, Juntao Yang, Jiangfeng Liu   +9 more
doaj   +1 more source

Effects of intraperitoneal injection of busulfan on metabolic characteristics of spermatogonial stem cells [PDF]

Jichu yixue yu linchuang
Objective To establish a mouse model treated with busulfan and to investigate its effects on the metabolism of spermatogonial stem cells (SSCs) of mouse testis.
YU Zhixin, MANG Xinyu, ZOU Dingfeng, MIAO Shiying, SONG Wei, LI Kai
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Discovery of Zharp1-163 as a dual inhibitor of ferroptosis and necroptosis for the treatment of inflammatory disorders and kidney injury

Cell Death Discovery
Dysregulation of cell death plays a critical role in the onset and progression of numerous human diseases. Distinct forms of regulated cell death, such as necroptosis and ferroptosis, have been implicated in the pathogenesis of various conditions ...
Yuting Ji, Shujing Du, Jingjing Li, Haikuo Ma, Xinhui Wang, Yongjin Hao, Zhanhui Li, Haohao Lu, Hao Liu, Chengkui Yang, Xiaohu Zhang, Sudan He   +11 more
doaj   +1 more source

Quantum Zeno Effect Explains Magnetic-Sensitive Radical-Ion-Pair Reactions

, 2009
Chemical reactions involving radical-ion pairs are ubiquitous in biology, since not only are they at the basis of the photosynthetic reaction chain, but are also assumed to underlie the biochemical magnetic compass used by avian species for navigation ...
C. Cohen-Tannoudji, I. K. Kominis, K. Schulten, S. G. Boxer, V. B. Braginsky   +4 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Posttranscriptional Control of Neural Progenitors Temporal Dynamics During Neocortical Development by Syncrip

Advanced Science
The development of the mammalian neocortex is precisely regulated by temporal gene expression, yet the temporal regulatory mechanisms of cortical neurogenesis, particularly how radial glial cells (RGCs) sequentially generate deep to superficial neurons ...
Jiarui Wu, Haoyang Yu, Xinyi Dou, Bin Yin, Lin Hou, Yuanchao Xue, Boqin Qiang, Pengcheng Shu, Xiaozhong Peng   +8 more
doaj   +1 more source

Computational modeling to elucidate molecular mechanisms of epigenetic memory

, 2015
How do mammalian cells that share the same genome exist in notably distinct phenotypes, exhibiting differences in morphology, gene expression patterns, and epigenetic chromatin statuses?
Alsing, Andrews, Ang, Angel, Arnold, Bannister, Barth, Beisel, Benecke, Bhattacharya, Binder, Black, Buscaino, Bushey, Canzio, Cowieson, David-Rus, Dayarian, Deal, Dodd, Fonseca, Freddolino, Gaffney, Grauffel, Greer, Grewal, Grigoryev, Hanna, Hathaway, Henikoff, Herranz, Hodges, Jacobs, Korolev, Korolev, Kouzarides, Ku, Kulaeva, Lin, Margreitter, Margueron, Mendenhall, Muller, Papp, Pasque, Peinado, Piana, Potoyan, Prohaska, Raghavan, Rohlf, Sanbonmatsu, Sanli, Schwab, Schwammle, Sedighi, So, Sontag, Steffen, Takahashi, Teif, Thon, Wocjan, Xu, Yang, Yuan, Zee, Zhang, Zhang   +68 more
core   +1 more source