Results 121 to 130 of about 2,474,961 (353)

Mechanism of Transcription. Cold Spring Harbor Symposium on Quantitative Biology Volume LXIII. Cold Spring Harbor Press. 1999. 679 pages. Cloth $258 ISBN 0 87969 550 1. Paper $110 ISBN 0 87969 552 8. [PDF]

, 2000
Richard S. Hayward
openalex   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

SEE: A Method for Predicting the Dynamics of Chromatin Conformation Based on Single‐Cell Gene Expression

Advanced Science
The dynamics of chromatin conformation involve continuous and reversible changes within the nucleus of a cell, which participate in regulating processes such as gene expression, DNA replication, and damage repair.
Minghong Li, Yurong Yang, Rucheng Wu, Haiyan Gong, Zan Yuan, Jixin Wang, Erping Long, Xiaotong Zhang, Yang Chen   +8 more
doaj   +1 more source

A Tead1-Apelin axis directs paracrine communication from myogenic to endothelial cells in skeletal muscle

iScience, 2022
Summary: Apelin (Apln) is a myokine that regulates skeletal muscle plasticity and metabolism and declines during aging. Through a yeast one-hybrid transcription factor binding screen, we identified the TEA domain transcription factor 1 (Tead1) as a novel
Umji Lee, Pascal Stuelsatz, Sonia Karaz, David W. McKellar, Julie Russeil, Maria Deak, Iwijn De Vlaminck, Christoph Lepper, Bart Deplancke, Benjamin D. Cosgrove, Jerome N. Feige   +10 more
doaj  

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

Effects of m6A methylation of MAT2A mRNA regulated by METTL16 on learning and memory, hippocampal synaptic plasticity and Aβ1–42 in 5 × FAD mice

Frontiers in Aging Neuroscience
BackgroundAlzheimer’s disease (AD) is a common neurodegenerative disorder affecting older adults, characterized by progressive cognitive decline and pathological features such as amyloid plaque deposition, neuronal loss, and synaptic reduction.
Huan Chen, Huan Chen, Fangzhen Guo, Fangzhen Guo, Yan Zhao, Yan Zhao, Wei Liu, Bingyu Chen, Bingyu Chen, Chang Wang, Chang Wang, Lining Huang, Lining Huang, Lining Huang, Sufang Jiang, Sufang Jiang, Sufang Jiang, Xiaowei Ma, Huiling Ren, Huiling Ren, Sha Li, Sha Li, Sha Li, Huixian Cui, Huixian Cui   +24 more
doaj   +1 more source

RNA Interference: Biology, Mechanism, and Applications [PDF]

, 2003
Neema Agrawal, Palakodeti V.N. Dasaradhi, Asif Mohmmed, Pawan Malhotra, Raj K. Bhatnagar, Sunil Kumar Mukherjee   +5 more
openalex   +1 more source

Mechanisms and kinetic assays of aminoacyl‐tRNA synthetases

FEBS Letters, EarlyView.
Igor Zivkovic, Morana Dulic, Ita Gruic‐Sovulj   +2 more
wiley   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

PWP1 is overexpressed in hepatocellular carcinoma and facilitates liver cancer cell proliferation

Heliyon
Identification of novel biomarkers for prediction of disease course and prognosis is needed to reduce morbidity of liver hepatocellular carcinoma (LIHC/HCC) patients.
Rong Huang, Fu Xu, Luying Su, Yan Lu, Wei Liu, Shuaihu Liu, Ling Yang, Liya Su, Wei Song   +8 more
doaj