Results 131 to 140 of about 2,453,415 (302)

Disrupted Signaling through the Fanconi Anemia Pathway Leads to Dysfunctional Hematopoietic Stem Cell Biology: Underlying Mechanisms and Potential Therapeutic Strategies [PDF]

, 2012
Anja Geiselhart, Amelie Lier, Dagmar Walter, Michael D. Milsom   +3 more
openalex   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

How does the brain remember? Distinct pathways for voluntary and involuntary recall. [PDF]

PLoS Biol
Hu X, Zeng S.
europepmc   +1 more source

S09A4 Rotary mechanisms of F1-ATPase revealed by molecular simulations(Mechanism of F_1-ATPase Molecular Motor-A Cross Talk among Single Molecule, Structural Biology, and Molecular Simulation Studies-)

, 2007
Nobuyasu Koga, Shoji Takada
openalex   +2 more sources

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

S09A3 Conformational changes of the catalytic subunit β in single F_1-ATPase molecules revealed by TIRF microscopy with polarization modulation(Mechanism of F_1-ATPase Molecular Motor-A Cross Talk among Single Molecule, Structural Biology, and Molecular Simulation Studies-)

, 2007
Tomoko Masaike, Fumie Koyama, Masasuke Yoshida, Kazuhiro Oiwa, Takayuki Nishizaka   +4 more
openalex   +2 more sources

A Systems Biology Approach to Understanding the Mechanisms of Action of Chinese Herbs for Treatment of Cardiovascular Disease [PDF]

, 2012
Bohui Li, Xue Xu, Xia Wang, Hua Yu, Xiuxiu Li, Weiyang Tao, Yonghua Wang, Ling Yang   +7 more
openalex   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

The role of ephaptic coupling and gap junctional coupling in modulating the initiation and dynamics of reentrant arrhythmias. [PDF]

PLoS One
Wei N, Tolkacheva EG.
europepmc   +1 more source

S09A6 Mechanism of chemical-mechanical energy conversion of FrATPase molecular motor studied by hybrid molecular simulations(Mechanism of F_1-ATPase Molecular Motor-A Cross Talk among Single Molecule, Structural Biology, and Molecular Simulation Studies-)

, 2007
Shigehiko Hayashi
openalex   +2 more sources