Results 141 to 150 of about 10,501,738 (419)
iScience, 2022 Summary: Apelin (Apln) is a myokine that regulates skeletal muscle plasticity and metabolism and declines during aging. Through a yeast one-hybrid transcription factor binding screen, we identified the TEA domain transcription factor 1 (Tead1) as a novel
Umji Lee +10 more
doaj
Stephane Leduc and the vital exception in the Life Sciences [PDF]
arXiv, 2015 Embryogenesis, the process by which an organism forms and develops, has long been and still is a major field of investigation in the natural sciences. By which means, which forces, are embryonic cells and tissues assembled, deformed, and eventually organized into an animal?
arxiv
Molecular Oncology, EarlyView.In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen +13 more
wiley +1 more source
iScience, 2022 Summary: In addition to cooperatively driving transcriptional programs, emerging evidence supports transcription factors interacting with one another to modulate the outcome of binding events.
James A. Heslop +2 more
doaj
Intra-molecular refrigeration in enzymes [PDF]
arXiv, 2009 We present a simple mechanism for intra-molecular refrigeration, where parts of a molecule are actively cooled below the environmental temperature. We discuss the potential role and applications of such a mechanism in biology, in particular in enzymatic reactions.
arxiv
Book Review: Energetics and Mechanisms in Radiation Biology [PDF]
, 1969 Patricia J. Lindop
openalex +1 more source
Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients
Molecular Oncology, EarlyView.Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha +6 more
wiley +1 more source
Identification of homologous protein models via 3D comparisons using predicted structures
STAR ProtocolsSummary: Recent advances in protein structure prediction enable 3D homology alignment and domain annotation using tertiary structures. Here, we present a protocol to identify homologous structures and annotate protein domains through in silico ...
Anyu Pan +4 more
doaj
iScience, 2022 Summary: CRISPR-associated Rossmann fold (CARF) domain signaling underpins modulation of CRISPR-Cas nucleases; however, the RtcR CARF domain controls expression of two conserved RNA repair enzymes, cyclase RtcA and ligase RtcB.
Ioly Kotta-Loizou +10 more
doaj
Systems biology derived source-sink mechanism of BMP gradient formation
eLife, 2017 A morphogen gradient of Bone Morphogenetic Protein (BMP) signaling patterns the dorsoventral embryonic axis of vertebrates and invertebrates. The prevailing view in vertebrates for BMP gradient formation is through a counter-gradient of BMP antagonists ...
Joseph Zinski +5 more
doaj +1 more source