Results 11 to 20 of about 2,557,809 (352)

Towards molecular systems biology of gene transcription and regulation [PDF]

open access: yes, 2010
Ten years after the determination of the RNA polymerase 11 structure, the basic mechanism of mRNA synthesis during gene transcription is known. In the future, the initiation and regulation of transcription must be studied with a combination of structural
Cramer, Patrick
core   +1 more source

In-organoid single-cell CRISPR screening reveals determinants of hepatocyte differentiation and maturation

open access: yesGenome Biology, 2023
Background Harnessing hepatocytes for basic research and regenerative medicine demands a complete understanding of the genetic determinants underlying hepatocyte differentiation and maturation.
Junbo Liang   +11 more
doaj   +1 more source

Epigenetics: Biology's Quantum Mechanics [PDF]

open access: yesFrontiers in Plant Science, 2011
The perspective presented here is that modern genetics is at a similar stage of development as were early formulations of quantum mechanics theory in the 1920s and that in 2010 we are at the dawn of a new revolution in genetics that promises to enrich and deepen our understanding of the gene and the genome. The interrelationships and interdependence of
openaire   +3 more sources

Proteomic and functional profiling of platelet-derived extracellular vesicles released under physiological or tumor-associated conditions

open access: yesCell Death Discovery, 2022
During hemostasis, thrombosis, and inflammation, activated blood platelets release extracellular vesicles (PEVs) that represent biological mediators of physiological and pathological processes.
Mauro Vismara   +8 more
doaj   +1 more source

Toward Mechanical Systems Biology in Bone [PDF]

open access: yesAnnals of Biomedical Engineering, 2012
ISSN:1573 ...
Trüssel, Andreas   +2 more
openaire   +3 more sources

Homeostasis as the Mechanism of Evolution. [PDF]

open access: yes, 2015
Homeostasis is conventionally thought of merely as a synchronic (same time) servo-mechanism that maintains the status quo for organismal physiology. However, when seen from the perspective of developmental physiology, homeostasis is a robust, dynamic ...
Torday, John S
core   +2 more sources

Carl F. Craver and Lindley Darden: \u3cem\u3eIn Search of Mechanisms: Discoveries Across the Life Sciences\u3c/em\u3e [PDF]

open access: yes, 2014
Carl Craver and Lindley Darden are two of the foremost proponents of a recent approach to the philosophy of biology that is often called the New Mechanism.
Glennan, Stuart
core   +2 more sources

Mechanisms in molecular biology [PDF]

open access: yes, 2017
The new mechanistic philosophy is divided into two largely disconnected projects. One deals with a metaphysical inquiry into how mechanisms relate to issues such as causation, capacities and levels of organization, while the other deals with epistemic issues related to the discovery of mechanisms and the intelligibility of mechanistic representations ...
openaire   +3 more sources

Studies on the cold tolerance of ratoon ‘Chaling’ common wild rice

open access: yesBiological Research, 2020
Background Rice is the staple food of many people around the world. However, most rice varieties, especially widely grown indica varieties and hybrids, are sensitive to cold stress.
Mengliang Xu   +5 more
doaj   +1 more source

Making serine integrases work for us [PDF]

open access: yes, 2017
DNA site-specific recombinases are enzymes (often associated with mobile DNA elements) that catalyse breaking and rejoining of DNA strands at specific points, thereby bringing about precise genetic rearrangements.
Stark, W. Marshall
core   +1 more source

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