Results 21 to 30 of about 5,467,308 (207)

In-organoid single-cell CRISPR screening reveals determinants of hepatocyte differentiation and maturation

open access: yesGenome Biology, 2023
Background Harnessing hepatocytes for basic research and regenerative medicine demands a complete understanding of the genetic determinants underlying hepatocyte differentiation and maturation.
Junbo Liang   +11 more
doaj   +1 more source

Toward Mechanical Systems Biology in Bone [PDF]

open access: yesAnnals of Biomedical Engineering, 2012
Cyclic mechanical loading is perhaps the most important physiological factor regulating bone mass and shape in a way which balances optimal strength with minimal weight. This bone adaptation process spans multiple length and time scales. Forces resulting from physiological exercise at the organ scale are sensed at the cellular scale by osteocytes ...
Trüssel, Andreas   +2 more
openaire   +4 more sources

Proteomic and functional profiling of platelet-derived extracellular vesicles released under physiological or tumor-associated conditions

open access: yesCell Death Discovery, 2022
During hemostasis, thrombosis, and inflammation, activated blood platelets release extracellular vesicles (PEVs) that represent biological mediators of physiological and pathological processes.
Mauro Vismara   +8 more
doaj   +1 more source

Epigenetics: Biology's Quantum Mechanics [PDF]

open access: yesFrontiers in Plant Science, 2011
The perspective presented here is that modern genetics is at a similar stage of development as were early formulations of quantum mechanics theory in the 1920s and that in 2010 we are at the dawn of a new revolution in genetics that promises to enrich and deepen our understanding of the gene and the genome. The interrelationships and interdependence of
openaire   +3 more sources

CRISPR-Cas: biology, mechanisms and relevance [PDF]

open access: yesPhilosophical Transactions of the Royal Society B: Biological Sciences, 2016
Prokaryotes have evolved several defence mechanisms to protect themselves from viral predators. Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated proteins (Cas) display a prokaryotic adaptive immune system that memorizes previous infections by integrating short sequences of invading genomes—termed spacers—into the ...
Frank Hille, Emmanuelle Charpentier
openaire   +4 more sources

Evolutionary cell biology: Functional insight from “Endless forms most beautiful” [PDF]

open access: yes, 2015
In animal and fungal model organisms, the complexities of cell biology have been analyzed in exquisite detail and much is known about how these organisms function at the cellular level.
Richardson, Elizabeth   +4 more
core   +1 more source

Studies on the cold tolerance of ratoon ‘Chaling’ common wild rice

open access: yesBiological Research, 2020
Background Rice is the staple food of many people around the world. However, most rice varieties, especially widely grown indica varieties and hybrids, are sensitive to cold stress.
Mengliang Xu   +5 more
doaj   +1 more source

Mechanical and Systems Biology of Cancer

open access: yesComputational and Structural Biotechnology Journal, 2018
18 pages, 3 ...
Spill, F, Bakal, C, Mak, M
openaire   +5 more sources

Quantum Mechanics and Biology

open access: yesBiophysical Journal, 1962
I should like to begin by saying that I feel very diffident about speaking on the subject which the organizers of this Conference invited me to discuss with you. What I have to say will inevitably be limited by the extreme superficiality of my acquaintance with modem biochemistry and biophysics.
openaire   +2 more sources

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