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Background Harnessing hepatocytes for basic research and regenerative medicine demands a complete understanding of the genetic determinants underlying hepatocyte differentiation and maturation.
Junbo Liang +11 more
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Toward Mechanical Systems Biology in Bone [PDF]
Cyclic mechanical loading is perhaps the most important physiological factor regulating bone mass and shape in a way which balances optimal strength with minimal weight. This bone adaptation process spans multiple length and time scales. Forces resulting from physiological exercise at the organ scale are sensed at the cellular scale by osteocytes ...
Trüssel, Andreas +2 more
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During hemostasis, thrombosis, and inflammation, activated blood platelets release extracellular vesicles (PEVs) that represent biological mediators of physiological and pathological processes.
Mauro Vismara +8 more
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Epigenetics: Biology's Quantum Mechanics [PDF]
The perspective presented here is that modern genetics is at a similar stage of development as were early formulations of quantum mechanics theory in the 1920s and that in 2010 we are at the dawn of a new revolution in genetics that promises to enrich and deepen our understanding of the gene and the genome. The interrelationships and interdependence of
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CRISPR-Cas: biology, mechanisms and relevance [PDF]
Prokaryotes have evolved several defence mechanisms to protect themselves from viral predators. Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated proteins (Cas) display a prokaryotic adaptive immune system that memorizes previous infections by integrating short sequences of invading genomes—termed spacers—into the ...
Frank Hille, Emmanuelle Charpentier
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Evolutionary cell biology: Functional insight from “Endless forms most beautiful” [PDF]
In animal and fungal model organisms, the complexities of cell biology have been analyzed in exquisite detail and much is known about how these organisms function at the cellular level.
Richardson, Elizabeth +4 more
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Studies on the cold tolerance of ratoon ‘Chaling’ common wild rice
Background Rice is the staple food of many people around the world. However, most rice varieties, especially widely grown indica varieties and hybrids, are sensitive to cold stress.
Mengliang Xu +5 more
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Mechanical and Systems Biology of Cancer
18 pages, 3 ...
Spill, F, Bakal, C, Mak, M
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I should like to begin by saying that I feel very diffident about speaking on the subject which the organizers of this Conference invited me to discuss with you. What I have to say will inevitably be limited by the extreme superficiality of my acquaintance with modem biochemistry and biophysics.
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