Results 31 to 40 of about 2,557,809 (352)
Bottom-up assembly of functional intracellular synthetic organelles by droplet-based microfluidics
, 2020 Bottom-up synthetic biology has directed most efforts toward the construction of artificial compartmentalized systems that recreate living cell functions in their mechanical, morphological, or metabolic characteristics.
Platzman, I. +3 more
core +1 more source
Coarse-grained model of entropic allostery [PDF]
, 2004 Many signaling functions in molecular biology require proteins to bind to substrates such as DNA in response to environmental signals such as the simultaneous binding to a small molecule. Examples are repressor proteins which may transmit information via
A. Cooper +13 more
core +3 more sources
Caloric restriction, Sirtuins, and cardiovascular diseases
Chinese Medical Journal. Caloric restriction (CR) is a well-established dietary intervention known to extend healthy lifespan and exert positive effects on aging-related diseases, including cardiovascular conditions. Sirtuins, a family of nicotinamide adenine dinucleotide (NAD+
Ziyu Wei +7 more
doaj +1 more source
Collective oscillation period of inter-coupled biological negative cyclic feedback oscillators [PDF]
, 2014 A number of biological rhythms originate from networks comprised of multiple cellular oscillators. But analytical results are still lacking on the collective oscillation period of inter-coupled gene regulatory oscillators, which, as has been reported ...
Doyle III, Francis J. +3 more
core +2 more sources
Regulatory Mechanisms in Stem Cell Biology [PDF]
Cell, 1997 Stem cells are a subject of intense and increasing interest because of their biological properties and potential medical importance. Unfortunately, the field has been difficult for the nonspecialist to penetrate, in part because of ambiguity about what exactly constitutes a stem cell.
Morrison, Sean J. +2 more
openaire +3 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel +3 more
wiley +1 more source
Enhancing homology-directed repair efficiency with HDR-boosting modular ssDNA donor
Nature CommunicationsDespite the potential of small molecules and recombinant proteins to enhance the efficiency of homology-directed repair (HDR), single-stranded DNA (ssDNA) donors, as currently designed and chemically modified, remain suboptimal for precise gene editing ...
Ying-Ying Jin +12 more
doaj +1 more source
Nature Communications, 2020 Water intake is critical to our life, and the subfornical organ in the brain involved in the control of this behavior. Here, the authors reveal that two distinct groups of CCK-producing neurons in the SFO suppress water intake according to the ...
Takashi Matsuda +4 more
doaj +1 more source
Electrowetting of a nano-suspension on a soft solid
, 2018 The wetting of solid surfaces can be manoeuvred by altering the energy balance at the interfacial region. While electric field acts favourably to spread a droplet on a rigid surface, this tendency may be significantly suppressed over soft surfaces ...
Chakraborty, Suman +3 more
core +1 more source
Is synthetic biology mechanical biology?
History and Philosophy of the Life Sciences, 2015 A widespread and influential characterization of synthetic biology emphasizes that synthetic biology is the application of engineering principles to living systems. Furthermore, there is a strong tendency to express the engineering approach to organisms in terms of what seems to be an ontological claim: organisms are machines.
openaire +3 more sources