Results 51 to 60 of about 2,557,809 (352)

Identification of the effect of cisplatin on the transcriptome of human hepatocellular carcinoma cell lines [PDF]

Jichu yixue yu linchuang
Objective To investigate the effect of cisplatin treatment on the transcriptional level of human liver cancer cells by conducting transcriptome sequencing analysis after treating human liver cancer cell lines with different concentrations of cisplatin ...
GUO Xin, JI Mengdie, WANG Qi, LI Xueyuan, CHEN Yang
doaj   +1 more source

Monte Carlo study of gating and selection in potassium channels

, 2011
The study of selection and gating in potassium channels is a very important issue in modern biology. Indeed such structures are known in all types of cells in all organisms where they play many important functional roles.
A. L. Hodgkin, A. M. J. VanDongen, B. Hille, Daniele Andreucci, Dario Bellaveglia, Emilio N. M. Cirillo, Silvia Marconi   +6 more
core   +1 more source

MicroED structure of the NaK ion channel reveals a Na+ partition process into the selectivity filter. [PDF]

, 2018
Sodium (Na+) is a ubiquitous and important inorganic salt mediating many critical biological processes such as neuronal excitation, signaling, and facilitation of various transporters.
Gonen, Tamir, Liu, Shian
core   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Genome-Wide RNAi Screening Identifies Novel Host Factors Involved in Influenza A Virus Infection in A549 Cells

Viruses
Influenza A virus (IAV) remains a major global health threat, and host-directed antivirals may help overcome rapid viral mutation and drug resistance.
Qingchao Zhang, Lifang Zhang, Xinmeng Yang, Wei Wang, Xiliang Wang, Chengyu Jiang, Fengming Huang, Yanli Zhang   +7 more
doaj   +1 more source

Mod/Resc Parsimony Inference [PDF]

, 2010
We address in this paper a new computational biology problem that aims at understanding a mechanism that could potentially be used to genetically manipulate natural insect populations infected by inherited, intra-cellular parasitic bacteria.
A.D. Korshunov, D. Poinsot, E. Prisner, H. Fleischner, H. Gruber, H. Merçot, J. Engelstadter, J. Flum, J. Guo, J. Orlin, O. Duron, R. Niedermeier, R.G. Downey, S. Tsukiyama, S.L. Dobson, S.R. Bordenstein   +15 more
core   +6 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Ferroptosis: mechanisms, biology and role in disease

Nature Reviews Molecular Cell Biology, 2021
The research field of ferroptosis has seen exponential growth over the past few years, since the term was coined in 2012. This unique modality of cell death, driven by iron-dependent phospholipid peroxidation, is regulated by multiple cellular metabolic pathways, including redox homeostasis, iron handling, mitochondrial activity and metabolism of amino
Xuejun Jiang, Brent R. Stockwell, Marcus Conrad   +2 more
openaire   +4 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

A viable kinase-inactive RIPK3 D143N mouse model reveals its scaffold function in driving TNF-induced inflammatory disorder

Cell Death Discovery
RIPK3 is a key regulator of necroptosis, but the specific roles of its kinase-dependent and -independent functions in disease pathogenesis remain poorly understood.
Yayun Du, Jingjing Li, Cong Zhao, Shouqiao Hou, Qiuye Li, Xiangping Xu, Zhanhui Li, Jiaying Qiu, Changyu Zhuang, Lifen Xie, Feng Ma, Xiaohu Zhang, Xiaoliang Yu, Sudan He   +13 more
doaj   +1 more source