Results 51 to 60 of about 5,467,308 (207)

Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy

Nature Communications, 2020
Fukutin-related protein (FKRP) catalyses the addition of ribitol-phosphate (RboP) to the O-mannosyl glycan of α-dystroglycan and mutations in FKRP cause dystroglycanopathy. Here the authors provide insights into its oligomerization and recognition of the
Naoyuki Kuwabara, Rieko Imae, Hiroshi Manya, Tomohiro Tanaka, Mamoru Mizuno, Hiroki Tsumoto, Motoi Kanagawa, Kazuhiro Kobayashi, Tatsushi Toda, Toshiya Senda, Tamao Endo, Ryuichi Kato   +11 more
doaj   +1 more source

Analysing GCN4 Translational Control in Yeast by Stochastic Chemical Kinetics Modelling and Simulation [PDF]

, 2011
Peer ...
You, Tao, Ian Stansfield, Romano, M Carmen, Alistair JP Brown, Coghill, George MacLeod, George M Coghill, M Carmen Romano, Stansfield, Ian, Brown, Alistair James Petersen, Tao You   +9 more
core   +1 more source

A viable kinase-inactive RIPK3 D143N mouse model reveals its scaffold function in driving TNF-induced inflammatory disorder

Cell Death Discovery
RIPK3 is a key regulator of necroptosis, but the specific roles of its kinase-dependent and -independent functions in disease pathogenesis remain poorly understood.
Yayun Du, Jingjing Li, Cong Zhao, Shouqiao Hou, Qiuye Li, Xiangping Xu, Zhanhui Li, Jiaying Qiu, Changyu Zhuang, Lifen Xie, Feng Ma, Xiaohu Zhang, Xiaoliang Yu, Sudan He   +13 more
doaj   +1 more source

Identification of homologous protein models via 3D comparisons using predicted structures

STAR Protocols
Summary: Recent advances in protein structure prediction enable 3D homology alignment and domain annotation using tertiary structures. Here, we present a protocol to identify homologous structures and annotate protein domains through in silico ...
Anyu Pan, Jieyi Shentu, Yangfan Zeng, Rong Guo, Yang Yu   +4 more
doaj   +1 more source

The silicon trypanosome [PDF]

, 2010
African trypanosomes have emerged as promising unicellular model organisms for the next generation of systems biology. They offer unique advantages, due to their relative simplicity, the availability of all standard genomics techniques and a long history
Bakker, BM, Barrett, M.P., Michael P. Barrett, Westerhoff, Hans V., Breitling, Rainer, Westerhoff, HV, Breitling, R., Bakker, Barbara M.; id_orcid, Girolami, M, Girolami, Mark, Breitling, R, Michels, Paul A. M., Girolami, M., Paul A. M. Michels, Barbara M. Bakker, Barrett, Michael P., Bakker, B.M., Westerhoff, H.V.; id_orcid, Krauth-Siegel, R.L., Bakker, Barbara M., Michels, PAM, R. Luise Krauth-siegel, Clayton, C, Matthews, K, Clayton, C., Keith Matthews, Bakker, B., Matthews, Keith; id_orcid, Clayton, Christine, Christine Clayton, Rainer Breitling, Krauth-Siegel, R. Luise, Mark Girolami, Michels, Paulus, Hans V. Westerhoff, ,, Matthews, K., Michels, P.A.M., Westerhoff, H.V., Barrett, MP, Westerhoff, Hans V.; id_orcid, Michels, Paul A M, Krauth-Siegel, RL, Matthews, Keith   +43 more
core   +2 more sources

Proteomic and Phosphoproteomic Characteristics of Multiple Brain Regions in Rhesus Macaques After SARS‐CoV‐2 Infection

MedComm
The SARS‐CoV‐2 Omicron variant is more contagious than the original Alpha variant and can still cause neurological symptoms, including cognitive impairment. To gain a deeper understanding of the molecular mechanisms underlying these neurological effects,
Qiaochu Wang, Yanan Zhou, Tao Ding, Yan Sun, Yehong Yang, Yue Wu, Jiangfeng Liu, Shuaiyao Lu, Juntao Yang   +8 more
doaj   +1 more source

Structural insights into the specificity of adaptor proteins Dok5 and Dok6 Docking to Trk receptors

Cell Communication and Signaling
Specific neurotrophic signaling by Trk receptors relies on the selective recruitment of downstream adaptors such as Dok5 and Dok6, yet the structural basis underlying this selectivity has remained unresolved.
Yingyao Wu, Xiaojiao Sun, Hongyue Chen, Bin Yin, Lin Hou, Boqin Qiang, Pengcheng Shu, Xiaozhong Peng   +7 more
doaj   +1 more source

Genome-Wide RNAi Screening Identifies Novel Host Factors Involved in Influenza A Virus Infection in A549 Cells

Viruses
Influenza A virus (IAV) remains a major global health threat, and host-directed antivirals may help overcome rapid viral mutation and drug resistance.
Qingchao Zhang, Lifang Zhang, Xinmeng Yang, Wei Wang, Xiliang Wang, Chengyu Jiang, Fengming Huang, Yanli Zhang   +7 more
doaj   +1 more source

Identification of the effect of cisplatin on the transcriptome of human hepatocellular carcinoma cell lines [PDF]

Jichu yixue yu linchuang
Objective To investigate the effect of cisplatin treatment on the transcriptional level of human liver cancer cells by conducting transcriptome sequencing analysis after treating human liver cancer cell lines with different concentrations of cisplatin ...
GUO Xin, JI Mengdie, WANG Qi, LI Xueyuan, CHEN Yang
doaj   +1 more source

RNA Interference: Biology, Mechanism, and Applications [PDF]

Microbiology and Molecular Biology Reviews, 2003
SUMMARY Double-stranded RNA-mediated interference (RNAi) is a simple and rapid method of silencing gene expression in a range of organisms. The silencing of a gene is a consequence of degradation of RNA into short RNAs that activate ribonucleases to target homologous mRNA.
Neema, Agrawal, P V N, Dasaradhi, Asif, Mohmmed, Pawan, Malhotra, Raj K, Bhatnagar, Sunil K, Mukherjee   +5 more
openaire   +2 more sources