Results 71 to 80 of about 1,244,390 (201)

PWP1 is overexpressed in hepatocellular carcinoma and facilitates liver cancer cell proliferation

Heliyon
Identification of novel biomarkers for prediction of disease course and prognosis is needed to reduce morbidity of liver hepatocellular carcinoma (LIHC/HCC) patients.
Rong Huang, Fu Xu, Luying Su, Yan Lu, Wei Liu, Shuaihu Liu, Ling Yang, Liya Su, Wei Song   +8 more
doaj   +1 more source

Effect of ergothioneine on tissue metabolism in middle-aged and aged mice [PDF]

Jichu yixue yu linchuang
Objective To investigate the effect of ergothioneine(EGT) on tissue metabolism in middle-aged and aged mice. Methods Nine-month-old middle-aged and aged C57BL/6J mice were selected to be gavaged with EGT aqueous solution at the dose and frequency of 35 ...
CHEN Haoran, WANG Fang, MA Yanni, YU Jia, WANG Lin
doaj   +1 more source

Proteome and ubiquitinome analyses of the brain cortex in K18-hACE2 mice infected with SARS-CoV-2

iScience
Summary: Clinical research indicates that SARS-CoV-2 infection is linked to several neurological consequences, and the virus is still spreading despite the availability of vaccinations and antiviral medications. To determine how hosts respond to SARS-CoV-
Qiaochu Wang, Wanjun Peng, Yehong Yang, Yue Wu, Rong Han, Tao Ding, Xutong Zhang, Jiangning Liu, Juntao Yang, Jiangfeng Liu   +9 more
doaj   +1 more source

Effects of intraperitoneal injection of busulfan on metabolic characteristics of spermatogonial stem cells [PDF]

Jichu yixue yu linchuang
Objective To establish a mouse model treated with busulfan and to investigate its effects on the metabolism of spermatogonial stem cells (SSCs) of mouse testis.
YU Zhixin, MANG Xinyu, ZOU Dingfeng, MIAO Shiying, SONG Wei, LI Kai
doaj   +1 more source

Discovery of Zharp1-163 as a dual inhibitor of ferroptosis and necroptosis for the treatment of inflammatory disorders and kidney injury

Cell Death Discovery
Dysregulation of cell death plays a critical role in the onset and progression of numerous human diseases. Distinct forms of regulated cell death, such as necroptosis and ferroptosis, have been implicated in the pathogenesis of various conditions ...
Yuting Ji, Shujing Du, Jingjing Li, Haikuo Ma, Xinhui Wang, Yongjin Hao, Zhanhui Li, Haohao Lu, Hao Liu, Chengkui Yang, Xiaohu Zhang, Sudan He   +11 more
doaj   +1 more source

Quantum Zeno Effect Explains Magnetic-Sensitive Radical-Ion-Pair Reactions

, 2009
Chemical reactions involving radical-ion pairs are ubiquitous in biology, since not only are they at the basis of the photosynthetic reaction chain, but are also assumed to underlie the biochemical magnetic compass used by avian species for navigation ...
C. Cohen-Tannoudji, I. K. Kominis, K. Schulten, S. G. Boxer, V. B. Braginsky   +4 more
core   +1 more source

Posttranscriptional Control of Neural Progenitors Temporal Dynamics During Neocortical Development by Syncrip

Advanced Science
The development of the mammalian neocortex is precisely regulated by temporal gene expression, yet the temporal regulatory mechanisms of cortical neurogenesis, particularly how radial glial cells (RGCs) sequentially generate deep to superficial neurons ...
Jiarui Wu, Haoyang Yu, Xinyi Dou, Bin Yin, Lin Hou, Yuanchao Xue, Boqin Qiang, Pengcheng Shu, Xiaozhong Peng   +8 more
doaj   +1 more source

Computational modeling to elucidate molecular mechanisms of epigenetic memory

, 2015
How do mammalian cells that share the same genome exist in notably distinct phenotypes, exhibiting differences in morphology, gene expression patterns, and epigenetic chromatin statuses?
Alsing, Andrews, Ang, Angel, Arnold, Bannister, Barth, Beisel, Benecke, Bhattacharya, Binder, Black, Buscaino, Bushey, Canzio, Cowieson, David-Rus, Dayarian, Deal, Dodd, Fonseca, Freddolino, Gaffney, Grauffel, Greer, Grewal, Grigoryev, Hanna, Hathaway, Henikoff, Herranz, Hodges, Jacobs, Korolev, Korolev, Kouzarides, Ku, Kulaeva, Lin, Margreitter, Margueron, Mendenhall, Muller, Papp, Pasque, Peinado, Piana, Potoyan, Prohaska, Raghavan, Rohlf, Sanbonmatsu, Sanli, Schwab, Schwammle, Sedighi, So, Sontag, Steffen, Takahashi, Teif, Thon, Wocjan, Xu, Yang, Yuan, Zee, Zhang, Zhang   +68 more
core   +1 more source

Atypical β-strand insertion mediates the noncovalent cross-linking in amyloid aggregates

Nature Communications
β-Strand motifs are essential recognition modules in protein-protein interactions (PPIs), which govern cellular signaling networks and regulate molecular pathway dynamics. Herein we present an unexpected discovery of a previously uncharacterized β-strand
Shanshan Mo, Ruonan Wang, Zhongyi Jian, Mingwei Liu, Feiyi Zhang, Zhun Deng, Wenbo Zhang, Yanlian Yang, Chen Wang, Lanlan Yu, Mingzhan Wang, Chenxuan Wang   +11 more
doaj   +1 more source

Network pharmacology-based screening and validation of tea-derived small molecules against lung cancer [PDF]

Jichu yixue yu linchuang
Objective To screen the active chemical components with potential therapeutic effects against lung cancer in tea and to provide new insights into the treatment and prevention of lung cancer.
YANG Rui, DU Sifen, JIANG Lehui, FU Tian, REN Pengju, JIANG Chengyu, ZHANG Yanli
doaj   +1 more source