Results 71 to 80 of about 2,036,755 (365)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

A Model of Multi-Finger Coordination in Keystroke Movement

open access: yesSensors
In multi-finger coordinated keystroke actions by professional pianists, movements are precisely regulated by multiple motor neural centers, exhibiting a certain degree of coordination in finger motions.
Jialuo Lin   +4 more
doaj   +1 more source

Mechanism design by observant and informed planners

open access: yes, 2022
We study the mechanism design problem where the planner can observe ex-post the first-ranked alternatives or peaks of voter preferences. We contrast this with the design problem where the planner has ex-ante information regarding the peaks of voter ...
CHATTERJI, Shurojit, SEN, Arunava
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tool wear influence on surface roughness, burrs and cracks in milling unidirectional carbon fiber reinforced plastics (UD-CFRP)

open access: yesJournal of Materials Research and Technology
This study delves into the machining defects encountered during the milling of Carbon Fiber Reinforced Plastics (CFRP), with a special focus on fishbone-like cracks on the machined surface, which have never been focused before.
Weizhou Wu   +6 more
doaj   +1 more source

Vibration Sensor-Based Bearing Fault Diagnosis Using Ellipsoid-ARTMAP and Differential Evolution Algorithms

open access: yesSensors, 2014
Effective fault classification of rolling element bearings provides an important basis for ensuring safe operation of rotating machinery. In this paper, a novel vibration sensor-based fault diagnosis method using an Ellipsoid-ARTMAP network (EAM) and a ...
Chang Liu   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Automated Identification and Representation of System Requirements Based on Large Language Models and Knowledge Graphs

open access: yesApplied Sciences
In the product design and manufacturing process, the effective management and representation of system requirements (SRs) are crucial for ensuring product quality and consistency.
Lei Wang   +5 more
doaj   +1 more source

Mechanism Design and Blockchains

open access: yesCoRR, 2020
Game theory is often used as a tool to analyze decentralized systems and their properties, in particular, blockchains. In this note, we take the opposite view. We argue that blockchains can and should be used to implement economic mechanisms because they can help to overcome problems that occur if trust in the mechanism designer cannot be assumed ...
Akaki Mamageishvili   +1 more
openaire   +2 more sources

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