Results 101 to 110 of about 3,910,323 (355)

Kinetic model based on molecular mechanism for action potential [PDF]

, 2011
The Hodgkin-Huxley model for action potentials has been widely used but was not built on a microscopic description of the neuronal membrane. Through molecular dynamics simulations, the molecular mechanism of the channel currents is becoming clear ...
Lizhong Xu
core   +1 more source

A New Approach to Non-Commutative U(N) Gauge Fields

, 2010
Based on the recently introduced model of arXiv:0912.2634 for non-commutative U(1) gauge fields, a generalized version of that action for U(N) gauge fields is put forward. In this approach to non-commutative gauge field theories, UV/IR mixing effects are
Armoni A., Attems M., Blaschke D. N., Blaschke D. N., Blaschke D. N., Blaschke D. N., Blaschke D. N., Blaschke D. N. Kronberger E. Sedmik R. I. P. Wohlgenannt M., Blaschke D. N. Rofner A. Sedmik R. I. P. Wohlgenannt M., D. N. Blaschke, Grosse H., Hayakawa M., Levell J., Matusis A., Minwalla S., Rivasseau V., Vilar L. C. Q.   +16 more
core   +1 more source

mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of Action [PDF]

, 2009
Ghada A. Soliman, Hugo A. Acosta-Jaquez, Elaine A. Dunlop, Bilgen Ekim, Nicole E. Maj, Andrew R. Tee, Diane C. Fingar   +6 more
openalex   +1 more source

Rituximab: Mechanism of Action [PDF]

Seminars in Hematology, 2010
Rituximab is a mainstay in the therapy for a broad variety of B-cell malignancies. Despite its undeniable therapeutic value, we still do not fully understand the mechanisms of action responsible for rituximab's anti-tumor effects. Direct signaling, complement-mediated cytotoxicity (CMC), and antibody-dependent cellular cytotoxicity (ADCC) all appear to
openaire   +2 more sources

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Mechanism of Anticonvulsant Action of ACTH

Pediatric Neurology Briefs, 2001
The hypothesis that systemic or intraventricular administration of corticotropin (ACTH) acts directly on limbic neurons to modulate corticotropin-releasing hormone (CRH) gene expression, independently of adrenal stimulation, was tested and confirmed in ...
J Gordon Millichap
doaj   +1 more source

Anomalous Diffusion at Edge and Core of a Magnetized Cold Plasma

, 2009
Progress in the theory of anomalous diffusion in weakly turbulent cold magnetized plasmas is explained. Several proposed models advanced in the literature are discussed.
Bohm, Callen J D, Chandrasekhar S, Kadomtsev B B, Kaufman H R, Mario J Pinheiro, Morozov A I, Morozov A I, Raspopović Z M, Reece J Roth, Richard, White R D, Zoran Raspopović   +12 more
core   +1 more source

Antioxidant Activity and Mechanisms of Action of Natural Compounds Isolated from Lichens: A Systematic Review [PDF]

, 2014
Pollyanna Alves Secundo White, Rita Oliveira, Aldeídia Pereira de Oliveira, Mairim Russo Serafini, Adriano Antunes de Souza Araújo, Daniel Pens Gelain, José Cláudio Fonseca Moreira, Jackson Roberto Guedes da Silva Almeida, Jullyana de Souza Siqueira Quintans, Lucindo José Quintans‐Júnior, Viviane Martins Rebello dos Santos   +10 more
openalex   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Mechanism of Anticonvulsant Action of ACTH

Pediatric Neurology Briefs, 1998
The effects of adrenocorticotrophin hormone (ACTH) in 23 children with intractable epilepsies and its mechanism of action are reported from the Department of Paediatric Neurology, Royal Hospital for Sick Children, Edinburgh, UK.
J Gordon Millichap
doaj   +1 more source