Results 121 to 130 of about 1,385,207 (269)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Thymol: properties, synthesis, mechanism of action, and applications. [PDF]

Front Nutr
Liu S, Lei J, Liu H, Chen T, Gao C, Luo D, Liao Q, Liu X, Chen J, Bonnave M, Serneels F, Luo X, Xie G, Dong P.   +13 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Mechanism of action of Houttuynia cordata extract and its application in animal production. [PDF]

Front Vet Sci
Xu D, Wang H, Lu S, Cao M, Tang W, Chen S, Yang S, Mei S, Zhu M, Na B, Liu X, Lei Y, Li X, Cheng Q, Chen C.   +14 more
europepmc   +1 more source

On the Mechanism of Action of Encephabol

Journal of International Medical Research, 1983
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The expression and mechanism of action of ADAMTS18 in endometrial cancer. [PDF]

J Mol Histol
Li X, Xu M, Guo X, Xu Y.
europepmc   +1 more source

Mechanism of transaminase action [PDF]

Biochemical Journal, 1961
T, OSHIMA, N, TAMIYA
openaire   +3 more sources

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

The major toxins of Bacillus cereus - Current knowledge on distribution, regulation and mechanism of action. [PDF]

EXCLI J
Albahri M, Jessberger N.
europepmc   +1 more source