Results 161 to 170 of about 175,059,218 (262)

Elranatamab: Mechanism of Action, Clinical, and Translational Science. [PDF]

Clin Transl Sci
Elmeliegy M, Viqueira A, Vandendries E, Soltantabar P, Lon HK, Poels K, Shtylla B, Irby D, Bompiani-Myers K, O'Brien T, Hibma J.   +10 more
europepmc   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Peer assisted teaching scheme and Participative Action Learning Action Research: A winning combination

, 2015
This paper demonstrates synergetic influences of systems thinking upon a third cycle of action research aimed at improve teaching skills and the student experience.
Cameron, Leone Carol
core  

Talquetamab: Mechanism of Action, Clinical, and Translational Science. [PDF]

Clin Transl Sci
Wang Y, Gong J, Au N, Zhou J, Yuan D, Tolbert J, Zhang G, Vishwamitra D, Zhang J, Haddish-Berhane N, Singh I.   +10 more
europepmc   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Exploration of the Mechanism of Action of Dendrobium officinale in the Treatment of Liver Cancer Based on Network Pharmacology, Molecular Docking and in vitro Validation

Journal of Hepatocellular Carcinoma
Shuimeng Zhan,1,* Xinyan Lu,1,* Hongyan Guo,1 Yang Liu,1 Zhi Li,1 Wei Xu,2 Fang Xia,2 Huanjun Tang,2 Yi Tian,2 Jing Chen,3 Xuan Lin1 1Department of Endocrinology, CR & WISCO General Hospital Affiliated to Wuhan University of Science ...
Zhan S, Lu X, Guo H, Liu Y, Li Z, Xu W, Xia F, Tang H, Tian Y, Chen J, Lin X   +10 more
doaj  

The mechanism of action and clinical efficacy of xanomeline-trospium in schizophrenia: A comprehensive review. [PDF]

Ther Adv Psychopharmacol
Ji F, Ma L, Shen X, Liang X, Cui W, Zhou Y, Wang XE, Liu H.   +7 more
europepmc   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Mechanism of action of a bactericidal lipopeptide which targets lipopolysaccharides of the plant pathogen <i>Xylella fastidiosa</i>. [PDF]

Front Plant Sci
Caravaca-Fuentes P, Riesco-Llach G, Gascón B, Feliu L, Planas M, Montesinos E.   +5 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source