Results 11 to 20 of about 37,966 (219)
Bisphosphonates: Mechanisms of Action [PDF]
Endocrine Reviews, 1998 The geminal bisphosphonates are a class of drug, developed in the last 30 years, characterised by a P-C-P bond. Consequently, they are analogues of pyrophosphate but are resistant to chemical and enzymatic hydrolysis. The bisphosphonates bind strongly to hydroxyapatite crystals and inhibit their formation and dissolution. This physicochemical effect on
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Marine Drugs, 2018 A novel wild-type recombinant cold-active α-d-galactosidase (α-PsGal) from the cold-adapted marine bacterium Pseudoalteromonas sp. KMM 701, and its mutants D451A and C494N, were studied in terms of their structural, physicochemical, and ...
Irina Bakunina +8 more
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Marine Drugs, 2018 A new melatonin analogue 6-hydroxy-N-acetyl-β-oxotryptamine (1) was isolated from the marine-derived fungus Penicillium sp. KMM 4672. It is the second case of melatonin-related compounds isolation from microfilamentous fungi.
Ekaterina A. Yurchenko +6 more
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The mechanisms of action of metformin [PDF]
Diabetologia, 2017 Metformin is a widely-used drug that results in clear benefits in relation to glucose metabolism and diabetes-related complications. The mechanisms underlying these benefits are complex and still not fully understood. Physiologically, metformin has been shown to reduce hepatic glucose production, yet not all of its effects can be explained by this ...
Rena, Graham +2 more
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Analgesic choice in dentistry. Part I: The mechanism of action
Brazilian Journal of Oral Sciences, 2015 Analgesics are frequently used in dentistry for the management of dental pain. Dental clinicians should choose the medicine based on its mechanism of action and toxicity, to promote a successful analgesic effect as well as comfort to the patient.
Filipe Polese Branco +3 more
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Pharmaceutics, 2021 We describe the design and attributes of a linear pentapeptide-like derivative (C14(ω5)OOc10O) screened for its ability to elicit bactericidal competences of plasma constituents against Gram-negative bacteria (GNB).
Fadia Zaknoon, Ohad Meir, Amram Mor
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An Exploration of the Mechanism of Action of an Equine-Assisted Intervention
Animals, 2019 Though long alluded to, there is now an accumulation of evidence of the vital contribution that emotion makes to learning. Within this broad advance in understanding is a growing body of research emphasising the embodied nature of this emotion-based ...
Ann Hemingway +4 more
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BIOMOLECULAR MECHANISM OF ANTI EPILEPTIC DRUGS
Malang Neurology Journal, 2018 Epilepsy therapy is almost always chronic and often used more than one drug. Currently, antiepileptic drugs are still the mainstay of therapy for epilepsy. An understanding of the pharmacodynamics and pharmacokinetics of these drugs would be very helpful
Machlusil Husna +1 more
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Alitretinoin in treatment of chronic hand eczema – mechanism of action
Przegląd Dermatologiczny, 2016 Hand eczema is a common skin disorder with significant functional and economic impacts. Conventional therapy options, such as topical corticosteroids, calcineurin inhibitors, phototherapy and systemic immunosuppressants, often give unsatisfactory results,
Maria Matejko, Beata Kręcisz
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Mechanism of action of microecologics and their application in dairy cows
Siliao yanjiu, 2022 As an efficient and green feed additive, microecologics can regulate the homeostasis of animal intestinal flora, improve animal immunity and promote productivity. Compared to animals with one stomach, dairy cows have special structure of digestive system
LIU Ping +7 more
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