Results 11 to 20 of about 1,438,950 (318)

Characterization of Properties and Transglycosylation Abilities of Recombinant α-Galactosidase from Cold-Adapted Marine Bacterium Pseudoalteromonas KMM 701 and Its C494N and D451A Mutants

open access: yesMarine Drugs, 2018
A novel wild-type recombinant cold-active α-d-galactosidase (α-PsGal) from the cold-adapted marine bacterium Pseudoalteromonas sp. KMM 701, and its mutants D451A and C494N, were studied in terms of their structural, physicochemical, and ...
Irina Bakunina   +8 more
doaj   +1 more source

Health Benefits and Pharmacological Properties of Carvone

open access: yesBiomolecules, 2021
Carvone is a monoterpene ketone contained in the essential oils of several aromatic and medicinal plants of the Lamiaceae and Asteraceae families. From aromatic plants, this monoterpene is secreted at different concentrations depending on the species ...
Abdelhakim Bouyahya   +9 more
doaj   +1 more source

ON THE MECHANISM OF ACTION OF ALDOSTERONE [PDF]

open access: yesProceedings of the National Academy of Sciences, 1969
Studies to elucidate the mode of action of aldosterone have been carried out in the amphibian urinary bladder. The following previously reported hypotheses were evaluated: (1) aldosterone stimulates sodium transport by increasing the amount of sodium available to the sodium pump; (2) aldosterone enhances energy production for the sodium ...
D B, Goodman, J E, Allen, H, Rasmussen
openaire   +2 more sources

Neuroprotective Activity of Some Marine Fungal Metabolites in the 6-Hydroxydopamin- and Paraquat-Induced Parkinson’s Disease Models

open access: yesMarine Drugs, 2018
A new melatonin analogue 6-hydroxy-N-acetyl-β-oxotryptamine (1) was isolated from the marine-derived fungus Penicillium sp. KMM 4672. It is the second case of melatonin-related compounds isolation from microfilamentous fungi.
Ekaterina A. Yurchenko   +6 more
doaj   +1 more source

Analgesic choice in dentistry. Part I: The mechanism of action

open access: yesBrazilian Journal of Oral Sciences, 2015
Analgesics are frequently used in dentistry for the management of dental pain. Dental clinicians should choose the medicine based on its mechanism of action and toxicity, to promote a successful analgesic effect as well as comfort to the patient.
Filipe Polese Branco   +3 more
doaj   +1 more source

Mechanistic Studies of Antibiotic Adjuvants Reducing Kidney’s Bacterial Loads upon Systemic Monotherapy

open access: yesPharmaceutics, 2021
We describe the design and attributes of a linear pentapeptide-like derivative (C14(ω5)OOc10O) screened for its ability to elicit bactericidal competences of plasma constituents against Gram-negative bacteria (GNB).
Fadia Zaknoon, Ohad Meir, Amram Mor
doaj   +1 more source

The mechanisms of action of metformin [PDF]

open access: yesDiabetologia, 2017
Metformin is a widely-used drug that results in clear benefits in relation to glucose metabolism and diabetes-related complications. The mechanisms underlying these benefits are complex and still not fully understood. Physiologically, metformin has been shown to reduce hepatic glucose production, yet not all of its effects can be explained by this ...
Rena, Graham   +2 more
openaire   +3 more sources

An Exploration of the Mechanism of Action of an Equine-Assisted Intervention

open access: yesAnimals, 2019
Though long alluded to, there is now an accumulation of evidence of the vital contribution that emotion makes to learning. Within this broad advance in understanding is a growing body of research emphasising the embodied nature of this emotion-based ...
Ann Hemingway   +4 more
doaj   +1 more source

BIOMOLECULAR MECHANISM OF ANTI EPILEPTIC DRUGS

open access: yesMalang Neurology Journal, 2018
Epilepsy therapy is almost always chronic and often used more than one drug. Currently, antiepileptic drugs are still the mainstay of therapy for epilepsy. An understanding of the pharmacodynamics and pharmacokinetics of these drugs would be very helpful
Machlusil Husna   +1 more
doaj   +1 more source

Alitretinoin in treatment of chronic hand eczema – mechanism of action

open access: yesPrzegląd Dermatologiczny, 2016
Hand eczema is a common skin disorder with significant functional and economic impacts. Conventional therapy options, such as topical corticosteroids, calcineurin inhibitors, phototherapy and systemic immunosuppressants, often give unsatisfactory results,
Maria Matejko, Beata Kręcisz
doaj   +1 more source

Home - About - Disclaimer - Privacy