Results 31 to 40 of about 37,966 (219)
Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin +17 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann +8 more
wiley +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono +7 more
wiley +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo +5 more
wiley +1 more source
MECHANISM OF ACTIONS OF ANTIDEPRESSANTS: BEYOND THE RECEPTORS
Psychiatry and Clinical Psychopharmacology, 2021 Since the discovery of first antidepressants-monoamine oxidase inhibitors- a half century passed. There are now almost twodozen antidepressant agents that work by nine distinct pharmacological mechanisms at the receptor level.
Ayşegül Yıldız +2 more
doaj
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa +7 more
wiley +1 more source
Application and research progress of cinnamaldehyde in animal husbandry
Siliao yanjiu, 2021 Cinnamaldehyde has a wide range of biological functions, which can improve animal intestinal flora and morphological structure, body immunity, production performance and meat quality.
Ke-ning WU +7 more
doaj
MECHANISM OF ACTION OF GUANETHIDINE [PDF]
British Journal of Pharmacology and Chemotherapy, 1962 The early hypotensive action of intravenous guanethidine in rabbits, rats and cats anaesthetized with urethane is reversed after pretreatment with iproniazid. The fall in blood pressure following injection of guanethidine in rabbits is reduced after previous administration of reserpine.
openaire +2 more sources
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito +7 more
wiley +1 more source
Sulodexide. Pharmacokinetics, pharmacodynamics, and mechanism of action
Clinical Management Issues, 2015 Sulodexide is a highly purified preparation containing glycosaminoglycans composed from heparin-like and dermatan fractions. It is similar to unfractionated heparin, but it shows a prolonged half-life, a higher bioavability and a reduced effect on ...
Luca Masotti
doaj +1 more source