Results 41 to 50 of about 37,966 (219)

Mechanisms of action of angiogenin [PDF]

Acta Biochimica et Biophysica Sinica, 2008
Angiogenin induces angiogenesis by activating vessel endothelial and smooth muscle cells and triggering a number of biological processes, including cell migration, invasion, proliferation, and formation of tubular structures. It has been reported that angiogenin plays its functions mainly through four pathways: (1) exerting its ribonucleolytic activity;
Xiangwei, Gao, Zhengping, Xu
openaire   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Antidepressant-like effects of gallic acid: dual effect on serotonergic and catecholaminergic neurotransmissions

Psychiatry and Clinical Psychopharmacology, 2021
Objective: Gallic acid (GA), 3,4,5-trihydroxybenzoic acid, is a phenolic acid derivative and a natural polyphenol found in tea leaves, grapes, berries and plants like Thuja, Quercus, Rhus, Camelia.
Nazli Turan, Ozgur Devrim Can, Yusuf Ozturk   +2 more
doaj  

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

On the Mechanism of Action of Aminopterin.

Experimental Biology and Medicine, 1950
SummaryRat liver slices form from synthetic folic acid (PGA) a factor (CF) utilized for growth by Leuconostoc citrovorum; this conversion is inhibited by aminopterin. In rats given PGA, a similar inhibition of the synthesis of CF is shown by a marked decrease in the urinary excretion of CF following the administration of aminopterin. The antagonist not
C A, NICHOL, A D, WELCH
openaire   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Depression, an unmet health need in Africa: Understanding the promise of ketamine

Heliyon
In Africa, there is currently a paucity of data on the epidemiology of depression, its treatment and management. The prevalence of depression is severely underestimated, with unique circumstances and societal risk factors associated with depression and ...
Aletta ME. Millen, William MU. Daniels, Sooraj Baijnath   +2 more
doaj   +1 more source

Traditional Chinese Medicine for Breast Cancer: A Review

Breast Cancer: Targets and Therapy, 2023
Rui-Qi Feng,1 De-Hui Li,2 Xu-Kuo Liu,1 Xiao-Hui Zhao,1 Qian-Er Wen,1 Ying Yang1 1Graduate School of Hebei University of Chinese Medicine, Shijiazhuang, Hebei Province, People’s Republic of China; 2Oncology Department II, the First Affiliated Hospital of ...
Feng RQ, Li DH, Liu XK, Zhao XH, Wen QE, Yang Y   +5 more
doaj  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source