Results 251 to 260 of about 1,539,032 (313)

Mechanism of Action of MAO's <i>Molecular Cousin</i>. [PDF]

ACS Catal
Urciuoli G, Zaccaria F, Zuccaccia C, Cipullo R, Budzelaar PHM, Menendez Rodriguez G, Tensi L, Vittoria A, Ehm C, Busico V, Macchioni A.   +10 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Ibrexafungerp: Mechanism of Action, Clinical, and Translational Science. [PDF]

Clin Transl Sci
Walley AH, Dupuis LN, Woodahl EL, Killam SR.   +3 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Mechanism of action of cisplatin on Na+/K+ ATPase of Caco-2 colon cells in vitro. [PDF]

PLoS One
Mourad R, Hodeify R, Kreydiyyeh S.
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

The Pyrazole Scaffold in Anticancer Drug Discovery: A Review of Synthetic Approaches, Structure-Activity Relationships, and Target-Based Mechanism of Action. [PDF]

Int J Mol Sci
K R K, Hacholli VB, Gackowski M, Pisklak DM, Kumar A, Szeleszczuk Ł.   +5 more
europepmc   +1 more source

The ubiquitin-proteasome system in Alzheimer's disease: mechanism of action and current status of treatment. [PDF]

Front Aging Neurosci
Jia S, Li Q, Rui X, Qin W, Zhang W, Dou J, Zhang X.   +6 more
europepmc   +1 more source

Defining the Mechanism of Action and Resistance of New <i>Mycobacterium abscessus</i> MmpL3 Inhibitors. [PDF]

ACS Chem Biol
Abdalla BJ, Giletto MB, Goksel Carpa N, Wilson AK, Ellsworth E, Abramovitch RB.   +5 more
europepmc   +1 more source

A Comparative Analysis of the Efficacy, Safety and Mechanism of Action of Flebogamma DIF, Fostamatinib and Romiplostim in Immune Thrombocytopenia. [PDF]

Life (Basel)
Akinyemi M, Ravi K, Tian F, Singh B.
europepmc   +1 more source