Results 231 to 240 of about 1,385,207 (269)
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Mechanism of Action of Somatostatin
Hormone Research, 2008The chain of events leading to the manifestation of the biological action of somatostatin are described. Internalization is mediated by cytoskeletal proteins in the presence of calmodulin. Transduction of the somatostatin message at the membrane level takes place through inhibition of cyclic AMP accumulation and blockade of cytosol calcium increases ...
M J, Toro +3 more
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Mechanism of Action of Aldosterone
Nature, 1969ALDOSTERONE stimulates sodium transport across some epithelia including the distal kidney tubules and the isolated toad bladder preparation1. The effects of this mineralocorticoid on sodium transport are blocked by puromycin, which prevents ribosomal protein synthesis, and by actinomycin D, which prevents the DNA-dependent elaboration of messenger RNA2,
A W, Cuthbert, E, Painter
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Mechanisms of action of isoniazid
Molecular Microbiology, 2006SummaryFor decades after its introduction, the mechanisms of action of the front‐line antituberculosis therapeutic agent isoniazid (INH) remained unclear. Recent developments have shown that peroxidative activation of isoniazid by the mycobacterial enzyme KatG generates reactive species that form adducts with NAD+ and NADP+ that are potent inhibitors ...
Graham S, Timmins, Vojo, Deretic
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Thrombosis Research, 1983
Aspirin, one of the oldest antiplatelet agents used for antithrombotic therapy, has been demonstrated to cause acetylation of the cyclo-oxygenase and irreversible inhibition of thromboxane synthesis for the life of the platelet. Aspirin has a similar effect upon the endothelial cyclo-oxygenase, but in contrast to that of the platelet, it is less ...
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Aspirin, one of the oldest antiplatelet agents used for antithrombotic therapy, has been demonstrated to cause acetylation of the cyclo-oxygenase and irreversible inhibition of thromboxane synthesis for the life of the platelet. Aspirin has a similar effect upon the endothelial cyclo-oxygenase, but in contrast to that of the platelet, it is less ...
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On the Mechanism of Action of RU486
Annals of the New York Academy of Sciences, 1991The molecular mechanism of action of the progesterone antagonist RU-486 is explained in terms of the known action of the progesterone receptor. RU-486 is a flat steroid molecule like progesterone but it also has a larger 11-beta aminophenyl substituent which apparently does not affect the affinity of binding of the antagonist to the receptor.
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Mechanism of gating and partial agonist action in the glycine receptor
Cell, 2021Timo Greiner +2 more
exaly
THE MECHANISM OF ACTION OF INSULIN
British Medical Bulletin, 1960P J, RANDLE, F G, YOUNG
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Mechanisms of action of methotrexate
Immunopharmacology, 2000L, Genestier +4 more
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