Results 231 to 240 of about 175,059,218 (262)

Transcriptomic comparison on the mechanism of action of four major constituent cannabinoids in hemp extract. [PDF]

J Cannabis Res
Gao X, Yourick MR, Campasino K, Zhao Y, Sepehr E, Vaught C, Sprando RL, Yourick JJ.   +7 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Mechanism of action of the sinus microbiome in postoperative recurrence of type 2 chronic rhinosinusitis and advances in targeted intervention. [PDF]

Front Immunol
Lin H, Shang L, Lu Y.
europepmc   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Mechanism of action and clinical application of autophagy in multiple sclerosis (Review). [PDF]

Int J Mol Med
Wang D, Fu Q, Zhao Y, Li G, Bai Y, Yang Y, Song H, Wang M, Fan H.   +8 more
europepmc   +1 more source

Mechanism of Action of <i>Hedyotis diffusa</i> Extract in a Rat Model of Acute Lung Injury Based on Transcriptomic Analysis. [PDF]

Biology (Basel)
Lu C, Yang X, Yang X.
europepmc   +1 more source

Cell painting and thermal proteome profiling for inference of drug targets and mechanism of action. [PDF]

Mol Syst Biol
Johansson C, Johansson M, Kasi PB, Larsson M, Jakobsson PJ, Göransson U, Carreras Puigvert J, Spjuth O, Jansson ET.   +8 more
europepmc   +1 more source

Mirvetuximab Soravtansine: Mechanism of Action, Clinical and Translational Science. [PDF]

Clin Transl Sci
Menon R, Bako E, Liu S, Stec J, Thakur S, Deutschman E, Ab O, Jain S.   +7 more
europepmc   +1 more source

Study on the mechanism of action of Kangfuxin liquid in alleviating DSS-induced ulcerative colitis in mice. [PDF]

Front Pharmacol
Yue Y, Sai N, Qu X, Qi X, Xiao Z, Shi R, Zhang Y, He J, Zhang Y, Qiang Y, Guan H.   +10 more
europepmc   +1 more source