Results 271 to 280 of about 1,539,032 (313)
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Mechanisms of antihormone action
The Journal of Steroid Biochemistry and Molecular Biology, 1992The mechanisms of action of two types of anti-hormones is discussed. Type I anti-hormones comprise the antiestrogen hydroxy-tamoxifen and the antiprogestin RU486, both of which promote DNA binding of the cognate receptors and, due to the activity of one of the two transcription activation functions of the estrogen and progesterone receptors, act as ...
Gronemeyer, H. +11 more
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The mechanism of action of psychotherapy
Bipolar Disorders, 2002Colom F. The mechanism of action of psychotherapy. Bipolar Disord 2002: 4(Suppl. 1): 102.
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Mechanism of action of bisphosphonates
Current Osteoporosis Reports, 2003In recent years, substantial progress has been made in understanding the mechanism for bisphosphonate suppression of bone turnover. Bisphosphonates can now be distinguished based on their molecular and cellular mechanisms of action. Simple bisphosphonates such as clodronate and etidronate inhibit bone resorption through induction of osteoclast ...
Alfred A, Reszka, Gideon A, Rodan
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Mechanisms of Action of Cryptenamine
Journal of Pharmaceutical Sciences, 1968The hypotensive effect of cryptenamine has been reported to be markedly attenuated by adrenalectomy or by treatment with N,N-diisopropyl-N′-isoamyl-N′-diethyl-aminoethylurea (P-286) in atropinized animals. Cryptenamine also appeared to potentiate the response of isoproterenol on β-adrenergic receptors.
M L, Jandhyala, J P, Buckley
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Thalidomide: Mechanisms of Action
International Reviews of Immunology, 2008The classification of thalidomide as an orphan drug with anti-inflammatory actions has led to its off-label use in conditions refractory to other medications. Although the observed clinical effects of thalidomide suggest it to have immunomodulatory capabilities, the mechanism of action is unclear.
Taraneh, Paravar, Delphine J, Lee
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Mechanism of Action of Somatostatin
Hormone Research, 2008The chain of events leading to the manifestation of the biological action of somatostatin are described. Internalization is mediated by cytoskeletal proteins in the presence of calmodulin. Transduction of the somatostatin message at the membrane level takes place through inhibition of cyclic AMP accumulation and blockade of cytosol calcium increases ...
M J, Toro +3 more
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Mechanism of Action of Aldosterone
Nature, 1969ALDOSTERONE stimulates sodium transport across some epithelia including the distal kidney tubules and the isolated toad bladder preparation1. The effects of this mineralocorticoid on sodium transport are blocked by puromycin, which prevents ribosomal protein synthesis, and by actinomycin D, which prevents the DNA-dependent elaboration of messenger RNA2,
A W, Cuthbert, E, Painter
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Mechanisms of action of isoniazid
Molecular Microbiology, 2006SummaryFor decades after its introduction, the mechanisms of action of the front‐line antituberculosis therapeutic agent isoniazid (INH) remained unclear. Recent developments have shown that peroxidative activation of isoniazid by the mycobacterial enzyme KatG generates reactive species that form adducts with NAD+ and NADP+ that are potent inhibitors ...
Graham S, Timmins, Vojo, Deretic
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Thrombosis Research, 1983
Aspirin, one of the oldest antiplatelet agents used for antithrombotic therapy, has been demonstrated to cause acetylation of the cyclo-oxygenase and irreversible inhibition of thromboxane synthesis for the life of the platelet. Aspirin has a similar effect upon the endothelial cyclo-oxygenase, but in contrast to that of the platelet, it is less ...
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Aspirin, one of the oldest antiplatelet agents used for antithrombotic therapy, has been demonstrated to cause acetylation of the cyclo-oxygenase and irreversible inhibition of thromboxane synthesis for the life of the platelet. Aspirin has a similar effect upon the endothelial cyclo-oxygenase, but in contrast to that of the platelet, it is less ...
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On the Mechanism of Action of RU486
Annals of the New York Academy of Sciences, 1991The molecular mechanism of action of the progesterone antagonist RU-486 is explained in terms of the known action of the progesterone receptor. RU-486 is a flat steroid molecule like progesterone but it also has a larger 11-beta aminophenyl substituent which apparently does not affect the affinity of binding of the antagonist to the receptor.
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