Results 101 to 110 of about 22,796,869 (307)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Beyond two-stage models for lung carcinogenesis in the Mayak workers: Implications for Plutonium risk

, 2015
Mechanistic multi-stage models are used to analyze lung-cancer mortality after Plutonium exposure in the Mayak-workers cohort, with follow-up until 2008.
Eidemüller, Markus, Sokolnikov, Mikhail E., Zöllner, Sascha   +2 more
core   +2 more sources

Mechanistic Modeling of Architectural Vulnerability Factor [PDF]

ACM Transactions on Computer Systems, 2015
Reliability to soft errors is a significant design challenge in modern microprocessors owing to an exponential increase in the number of transistors on chip and the reduction in operating voltages with each process generation. Architectural Vulnerability Factor (AVF) modeling using microarchitectural simulators enables architects to make informed ...
Arun Arvind Nair, Stijn Eyerman, Jian Chen, Lizy Kurian John, Lieven Eeckhout   +4 more
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Using mechanistic animal growth models to estimate genetic parameters of biological traits

Animal, 2007
Mechanistic animal growth models can incorporate a description of the genotype as represented by underlying biological traits that aim to specify the animal's genetic potential for performance, independent from the environmental factors captured by the ...
A.B. Doeschl-Wilson, P.W. Knap, B.P. Kinghorn, H.A.M. Van der Steen   +3 more
doaj   +1 more source

Plasmodesmata Conductivity Regulation: A Mechanistic Model [PDF]

Plants, 2019
Plant cells form a multicellular symplast via cytoplasmic bridges called plasmodesmata (Pd) and the endoplasmic reticulum (ER) that crosses almost all plant tissues. The Pd proteome is mainly represented by secreted Pd-associated proteins (PdAPs), the repertoire of which quickly adapts to environmental conditions and responds to biotic and abiotic ...
Dorokhov, Yuri L., Ershova, Natalia M., Sheshukova, Ekaterina V., Komarova, Tatiana V.   +3 more
openaire   +2 more sources

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Agent‐based versus correlative models of species distributions: Evaluation of predictive performance with real and simulated data

Methods in Ecology and Evolution
Species distribution models (SDMs) have been widely used in ecology to understand how species relate to environmental variation. Most SDMs are correlative, and they lack explicit reference to the underlying processes, and therefore, the reliability of ...
Jukka Sirén, Panu Somervuo, Otso Ovaskainen   +2 more
doaj   +1 more source

Genome-wide chromosome architecture prediction reveals biophysical principles underlying gene structure

Cell Genomics
Summary: Classical observations suggest a connection between 3D gene structure and function, but testing this hypothesis has been challenging due to technical limitations.
Michael Chiang, Chris A. Brackley, Catherine Naughton, Ryu-Suke Nozawa, Cleis Battaglia, Davide Marenduzzo, Nick Gilbert   +6 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source