Results 51 to 60 of about 11,335 (213)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Universal differential equations as a unifying modeling language for neuroscience

Frontiers in Computational Neuroscience
The rapid growth of large-scale neuroscience datasets has spurred diverse modeling strategies, ranging from mechanistic models grounded in biophysics, to phenomenological descriptions of neural dynamics, to data-driven deep neural networks (DNNs).
Ahmed El-Gazzar, Marcel van Gerven
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Impacts of reopening strategies for COVID-19 epidemic: a modeling study in Piedmont region

BMC Infectious Diseases, 2020
Background Severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), the causative agent of the coronavirus disease 19 (COVID-19), is a highly transmittable virus.
Simone Pernice, Paolo Castagno, Linda Marcotulli, Milena Maria Maule, Lorenzo Richiardi, Giovenale Moirano, Matteo Sereno, Francesca Cordero, Marco Beccuti   +8 more
doaj   +1 more source

Mechanistic models project bird invasions with accuracy

Nature Communications, 2023
Invasive species pose a major threat to biodiversity and inflict massive economic costs. Effective management of bio-invasions depends on reliable predictions of areas at risk of invasion, as they allow early invader detection and rapid responses.
Diederik Strubbe, Laura Jiménez, A. Márcia Barbosa, Amy J. S. Davis, Luc Lens, Carsten Rahbek   +5 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Mechanistic Models of Virus–Bacteria Co-Infections in Humans: A Systematic Review of Methods and Assumptions

Pathogens
Background: Viral–bacterial co-infections can amplify disease severity through complex biological mechanisms. Mathematical models are critical tools for understanding these threats, but it is unclear how well they capture the underlying biology.
Mani Dhakal, Brajendra K. Singh, Rajeev K. Azad   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Agent‐based versus correlative models of species distributions: Evaluation of predictive performance with real and simulated data

Methods in Ecology and Evolution
Species distribution models (SDMs) have been widely used in ecology to understand how species relate to environmental variation. Most SDMs are correlative, and they lack explicit reference to the underlying processes, and therefore, the reliability of ...
Jukka Sirén, Panu Somervuo, Otso Ovaskainen   +2 more
doaj   +1 more source