Results 81 to 90 of about 28,987 (311)

THE MECHANICS AND MECHANISMS OF TOURISM BROKERING

open access: yesEthnologia Europaea, 2018
Although most forms of tourism are, and have always been, highly mediated activities, surprisingly little scholarly attention has been given to the crucial role of human brokers in tourism.
openaire   +2 more sources

The mechanism of dishabituation [PDF]

open access: yesFrontiers in Integrative Neuroscience, 2014
The dual-process theory of habituation attributes dishabituation, an increase in responding to a habituated stimulus after an interpolated deviant, to sensitization, a change in arousal. Our previous investigations into elicitation and habituation of the electrodermal orienting reflex (OR) showed that dishabituation is independent of sensitization for ...
Steiner, Genevieve Z. (R18023)   +1 more
openaire   +4 more sources

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Prospects of Mechanization in Direct Seeded Rice: A Comprehensive Review [PDF]

open access: yesJournal of Agricultural Machinery
The traditional method of transplanting rice seedlings is labor-intensive, prompting a shift towards direct seeding of rice as an alternative crop establishment method.
S. Manoj Kumar   +4 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

The Status of Labor-Saving Mechanization in Fruits and Vegetables [PDF]

open access: yes
The objective of this paper is to examine the status of labor-saving mechanization in U.S. fruit and vegetable harvesting. Fruit and vegetable harvest mechanization has several potential advantages: reduced harvest costs, eliminate problems associated ...
Wallace E. Huffman
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

3rd Regional forum on sustainable agricultural mechanization in Asia and the Pacific : human resource development for sustainable agricultural mechanization, 9-11 December 2015, Manila, the Philippines [PDF]

open access: yes, 2015
This synthesis report comprises of the proceedings of the 3rd Regional Forum on Sustainable Agricultural Mechanization in Asia and the Pacific, held on 9-11 December 2015 in Manila, the Philippines.
UN.ESCAP   +1 more
core  

Agricultural mechanization patterns in Nigeria: Insights from farm household typology and agricultural household model simulation [PDF]

open access: yes, 2021
Anecdotal evidence indicates labor costs for farming in Nigeria are rising while levels of mechanization remain low. Information is scarce regarding the types of farm households that use mechanization in Nigeria and the potential demand for mechanization
Takeshima, Hiroyuki; Nin-Pratt, Alejandro; Diao, Xinshen   +1 more
core  

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