Results 171 to 180 of about 18,551 (276)

Nuclear mechanobiology: a brief history and five unresolved questions. [PDF]

Nucleus
Lammerding J, Eeftens J, Gundersen GG, King MC, Lele TP, Li S, Luxton G W G, Medalia O, Piel M, Roca-Cusachs P, Renkawitz J, Roux K, Starr DA, Strom AR, Thiam HR, Wickström SA, Worman HJ.   +16 more
europepmc   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

CHARACTERIZATION OF NODAL ACTIN NETWORK: FUNCTIONS OF MYOSIN II, FILAMIN A AND FORMIN DAAM1

, 2014
Ph.DPH.D.
LUO WEIWEI
core  

Matrix Architecture and Integrin Branch Balance Distinguish Immune-Regulatory States in Clear Cell Renal Cell Carcinoma. [PDF]

Curr Issues Mol Biol
Karaca C, Arayici ME, Semiz HS, Ellidokuz H, Basbinar Y.   +4 more
europepmc   +1 more source

Real‐Time Stress Visualization of Hydrogels Enabled by Supramolecularly Switched Stretch‐Induced Phase Separation

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Supramolecular hydrogels enable real‐time visualization of mechanical stress through supramolecular switching mechanotransduction. Adamantane‐modified cellulose functions as a responsive domain that undergoes an on–off transition between hydrated and dehydrated states via reversible β‐cyclodextrin–adamantane complexation and decomplexation.
Sooyeon Noh, Akihide Sugawara, Naoaki Ishihara, Takashi Konishi, Yuki Ueda, Ryuhei Motokawa, Yoshinori Takashima, Hiroshi Uyama   +7 more
wiley   +1 more source

Correction: Photoenergy harvesting by ammonium molybdate soft hydrogel drops. [PDF]

Light Sci Appl
Lu Z, Hang X, Zhao Z, Cheng L, Zeng Y, Li B, Tian M, Liu B, Shan X, Zhu H, Wang Z, Ma M, Wang J, Gong Y, Zhong X, Wang Y, Chang L, Wang F.   +17 more
europepmc   +1 more source

Stiffness‐Activated Stellate Cells Drive Pancreatic Cancer Liver Colonization via GMFG‐TNS4 Signaling

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Fibrotic liver stiffness activates hepatic stellate cells through Piezo1‐dependent calcium influx and ER stress, promoting EV‐associated GMFG release. Delivered GMFG engages TNS4 in pancreatic cancer cells, triggering FAK/AKT signaling, adhesion, and fatty acid synthesis.
Biwen Zhu, Jian Wan, Xue Zhang, Jiashuai Yan, Xi Chen, Xiaoqi Guan, Qianqian Ren, Tao Yang, Di Wu, Qingsong Guo, Yibing Guo, Yuhua Lu   +11 more
wiley   +1 more source

Recent Advances in Mechanobiology-Mediated In Situ Tissue Engineering. [PDF]

Int J Biomater
Agbe H, Jaato BN, Dadzie DA, Frimpong BM, Mensah PM, Appiah MK, Dodoo-Arhin D, Kabla A.   +7 more
europepmc   +1 more source

Dielectric Elastomer Actuators as Safe and Effective Tools for Mechanostimulation of Human Cells

Advanced Intelligent Systems, Volume 8, Issue 9, September 2026.
Replicating physiological forces is crucial for realistic cell models. Dielectric elastomer actuators (DEAs) offer a soft alternative, though their high voltages raised toxicity concerns. We demonstrate that DEA stimulation causes no cell damage, cell death or cell‐cycle disruption, while activating mechanosensitive responses.
Simon Holzer, Chaimae Bahou, Noe Syfrig, Katia Monastyrskaya, Yoan Civet, Ali Hashemi Gheinani, Yves Perriard   +6 more
wiley   +1 more source

RECRUITMENT OF VINCULIN DURING TALIN STRETCHING

, 2016
Ph.DPH.D.
HU XIAN
core