Results 171 to 180 of about 35,268 (338)
Nature CommunicationsChromatin organization regulates gene expression, with nanoscale heterochromatin domains playing a fundamental role. Their size varies with microenvironmental stiffness and epigenetic interventions, but how these factors regulate their formation and ...
Vinayak Vinayak +7 more
doaj +1 more source
, 2018 Ischemia leading to heart attacks and strokes is the major cause of deaths in the world. Whether an occlusion occurs or not, depends on the ability of a growing thrombus to resist forces exerted on its structure.
Chandran, Vishnu Deep +3 more
core +1 more source
Responsive Materials, EarlyView.This Perspective discusses the potential of stimuli‐responsive liquid crystal polymer bio‐interfaces in modulating cell behavior as next generation dynamic artificial scaffolds. Unlike current artificial biomaterials that have static properties, LCPs offer fast, reversible, and spatially programmable deformation that reflects the dynamic properties of ...
Ruth M. C. Verbroekken +2 more
wiley +1 more source
Photodegradable Hydrogels for On‐Demand Modeling of Age‐Related Spatiotemporal ECM Deformation
Small, EarlyView.A light‐tunable PEG hydrogel enables on‐demand, spatiotemporal modeling of drusen‐like ECM bulges in the aging outer retina. By precisely controlling bulge size, the platform reveals how retinal pigment epithelium morphology adapts to topographical changes without disrupting actin cytoskeleton or polarity, effectively mimicking early ageing before ...
Felix Reul +8 more
wiley +1 more source
APL BioengineeringHow forces and mechanics influence and regulate living cells remains elusive. Mechanomemory, the response to a mechanical perturbation that persists after the perturbation is removed, is believed to be a key to understanding the impact of forces and ...
Fazlur Rashid +3 more
doaj +1 more source
Small, EarlyView.This work presents a 3D hybrid tissue scaffold inspired by bone, incorporating collagen, fabricated using multiphoton lithography. The mechanical properties of collagen are tunable, and biodegradation allows for time‐dependent changes in geometry. The results demonstrate enhanced osteogenic differentiation of stem cells in our hybrid scaffolds.
Christoph Naderer +7 more
wiley +1 more source
A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer
The FEBS Journal, EarlyView.Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou +4 more
wiley +1 more source
Beyond the chaos: How architecture structures tumour biology
The FEBS Journal, EarlyView.Tissue architecture shapes tumour initiation and progression through multiple interconnected layers continuously remodelled over time. This review outlines how physical forces, biochemical cues, cellular niches and systemic influences contribute to tumour evolution.
Lea Dörner +3 more
wiley +1 more source