Results 151 to 160 of about 18,551 (276)

Vascular smooth muscle cell mechanotransduction: Pathways, phenotypes and emerging technologies

The Journal of Physiology, EarlyView.
Abstract figure legend Vascular smooth muscle cells are exposed to mechanical stimuli from the blood flow and the extracellular matrix. The cells sense the signals from cyclic stretch, shear stress, hydrostatic pressure and matrix stiffness through specialized mechanosensors, such as mechanosensitive ion channels or cell surface receptors including ...
Nivethitha Kota Lakshminaraasimulu, Rachel E. A. Smyth, Aishwarya Prakash, Thomas Iskratsch   +3 more
wiley   +1 more source

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

The Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise, Qinglu Li, Mary G. Garry   +2 more
wiley   +1 more source

STUDY THE ROLE OF MICRO-NICHES IN EPITHELIAL APLICAL-BASAL POLARISATION

, 2016
Ph.DPH.D.
WENG ZHE
core  

NOVEL MECHANISMS IN THE REGULATION OF PERINUCLEAR ACTIN ASSEMBLY [PDF]

, 2014
Ph.DPH.D.
SHAO XIAOWEI
core  

Targeted immunotherapy rescues pulmonary fibrosis by reducing activated fibroblasts and regulating alveolar cell profile

Nature Communications
Idiopathic pulmonary fibrosis (IPF) is a severe lung disease occurring throughout the world; however, few clinical therapies are available for treating this disorder.
Jing Yan, Song-Yu Wang, Qi Su, Min-Wen Zou, Zi-Yue Zhou, Jian Shou, Yunlong Huo   +6 more
doaj   +1 more source

Structurally Cascaded Physics‐Informed Graph Neural Networks for Mechanotransduction‐Aware Tumor Microenvironment Modeling

Applied Research, Volume 5, Issue 5, October 2026.
This study introduces a structurally cascaded physics‐informed graph neural network to model tumor microenvironments accurately. By enforcing a directional dependency from mechanical strain to biochemical secretion, the method eliminates unphysical artifacts and significantly improves predictive accuracy for precision healthcare applications.
Xinyuan Chen, Nurashikin Saaludin, Mohd Nizam Husen   +2 more
wiley   +1 more source

SPATIAL MECHANICAL REGULATION OF EPHA2-INTEGRIN SIGNALING

, 2017
Ph.DPH.D.
CHEN ZHONGWEN
core  

A 3D‐Bioprinted, Cell‐Guiding Hydrogel Patch Promotes Functional Repair of Abdominal Incisions via Anisotropic ECM Remodeling

Smart Medicine, Volume 5, Issue 5, October 2026.
Abdominal incisions can heal into mechanically weak, disorganized scars. We developed a 3D‐bioprinted hydrogel patch with cell‐laden filaments oriented perpendicular to the incision, providing a guiding scaffold for local repair cells. This architecture supports organized collagen deposition and improves mechanical restoration of the healing abdominal ...
Tianxing Gong, Hao Li, Xueqiang Peng, Xinwei Liu, Xinyan Zhang, Qiushi Tang, Stephanie Willerth, Mario Taba Junior, Ricardo M. Carvalho, Hailong Yu, Shibo Wei, Hangyu Li   +11 more
wiley   +1 more source

EXPANSION AND CHARACTERIZATION OF HUMAN BREAST CIRCULATING CANCER CELLS [PDF]

, 2015
Ph.DPH.D.
KHOO BEE LUAN
core  

Mechanotransduction of Magnetically Applied Forces Leads to Mechanical Stiffening of Platelet‐Rich Plugs

Advanced Healthcare Materials, Volume 15, Issue 34, 11 September 2026.
A microfluidic device with magnetic microposts was used to assess platelet mechanobiology. The oscillatory actuation of posts with embedded iron particles was dampened by the dynamic stiffening of the platelet‐rich plugs. This stiffening process increased with applied load, but inhibiting platelet activation (ASA) or myosin contractility (blebbistatin)
Nikita Taparia, Ava M. Obenaus, Yoeur‐Man T. Mach, Nakul Sridhar, Nathan J. Sniadecki   +4 more
wiley   +1 more source