Results 131 to 140 of about 35,268 (338)
Biomimetic and Biophysical Approach to Profile Metastatic Cancer Cell Migration [PDF]
, 2018 Honors Research ScholarshipCancer metastasis is a complex process by which cells in a primary tumor acquire an aggressive phenotype, and travel to distant, secondary sites in the body.
Enders, Jacob
core
Mechanobiology in medicineType 1 hypersensitivity involves an exaggerated immune reaction triggered by allergen exposure, leading to rapid release of inflammatory mediators. Meanwhile, mechanobiology explores how physical forces influence cellular processes, and recent research ...
H. Sutanto
semanticscholar +1 more source
Advanced Science, EarlyView.Tumor metastasis results from complex interactions between cancer cells and mechanical microenvironments. We propose a “nucleus‐centered, cross‐stage mechanical signal decoding” model, highlighting how nuclear mechanosensors interpret forces at different stages.
Linqi Song +4 more
wiley +1 more source
The living aortic valve: From molecules to function. [PDF]
, 2014 The aortic valve lies in a unique hemodynamic environment, one characterized by a range of stresses (shear stress, bending forces, loading forces and strain) that vary in intensity and direction throughout the cardiac cycle.
Bertazzo, S +5 more
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Small ScienceEukaryotic cells possess the remarkable ability to sense and respond to mechanical cues from their extracellular environment, a phenomenon known as mechanobiology, which is crucial for the proper functioning of biological systems.
Prabuddha De Saram +3 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study presents a perfusable 3D bioengineered liver sinusoid platform that integrates biofabrication, 3D cell culture, controlled hemodynamics, and multiparametric characterization to model Fontan‐associated liver disease. By decoupling pressure and hypoxia effects, the system reveals early mechanobiological and profibrotic responses under ...
Sarah Rezapourdamanab +14 more
wiley +1 more source
The asymptotic homogenization elasticity tensor properties for composites with material discontinuities [PDF]
, 2016 The classical asymptotic homogenization approach for linear elastic composites with discontinuous material properties is considered as a starting point. The sharp length scale separation between the fine periodic structure and the whole material formally
Gerisch, Alf, Penta, Raimondo
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From sequence to mechanobiology? Promises and challenges for AlphaFold 3
Mechanobiology in medicineInteractions between macromolecules orchestrate many mechanobiology processes. However, progress in the field has often been hindered by the monetary and time costs of obtaining reliable experimental structures.
Francesco Zonta, Sergio Pantano
semanticscholar +1 more source
Advanced Science, EarlyView.Compared to a healthy random nanofibrous fibronectin microenvironment, a fibrotic aligned nanofibrous fibronectin microenvironment employs a specific integrin, α5β1 integrin, to activate early pro‐fibrotic fibroblast behaviors and later fibrotic fibroblast tissue formation with cell/F‐actin alignment, α‐SMA expression, and cell‐driven aligned ...
Doğuhan Beyatlı +3 more
wiley +1 more source