Results 111 to 120 of about 35,268 (338)

Liver Stiffness Directs Intrahepatic Cholesterol Accumulation Through YAP/TAZ in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
Liver stiffness promotes intrahepatic cholesterol accumulation by repressing LXRα through YAP/TAZ activation. Stiff matrices impair cholesterol efflux in hepatocytes, while YAP/TAZ deletion restores LXRα activity and prevents cholesterol‐induced fibrosis.
Na Young Lee, Myeung Gi Choi, Ho Jae Ryu, Young Jin Min, Seon Min Kim, Yeonseok Chung, Bo Kyung Koo, Yun Pyo Kang, Won Kim, Ja Hyun Koo   +9 more
wiley   +1 more source

Advances in cancer mechanobiology: Metastasis, mechanics, and materials

APL Bioengineering
Within the tumor microenvironment (TME), tumor cells are exposed to numerous mechanical forces, both internally and externally, which contribute to the metastatic cascade.
Abigail J. Clevenger, Maygan K McFarlin, J. P. M. Gorley, Spencer C Solberg, Anirudh K. Madyastha, Shreya A Raghavan   +5 more
semanticscholar   +1 more source

Timing Mechanotransduction: Mechanically Dynamic Biomaterials Reveal the Temporal Hierarchy of YAP/TAZ Control Nodes

Advanced Science, EarlyView.
This work develops dynamically softening polyacrylamide hydrogels for time‐resolved imaging during continuous mechanical transitions. The study revealed that mechanotransduction is biphasic; YAP/TAZ inactivation is driven by early loss of the nucleocytoskeletal continuum connecting subnuclear adhesions, F‐actin, and the nuclear envelope, coupled with ...
Alessandro Gandin, Giada Vanni, Veronica Torresan, Margherita Pelosin, Rebecca Busetto, Anna Citron, Ambela Suli, Paolo Contessotto, Carlo Albanese, Francesca Zanconato, Tito Panciera, Stefano Piccolo, Giovanna Brusatin   +12 more
wiley   +1 more source

Estimating prognosis in patients with acute myocardial infarction using personalized computational heart models [PDF]

, 2017
Biomechanical computational models have potential prognostic utility in patients after an acute ST-segment–elevation myocardial infarction (STEMI). In a proof-of-concept study, we defined two groups (1) an acute STEMI group (n = 6, 83% male, age 54 ± 12 ...
Berry, Colin, Carrick, David, Gao, Hao, Husmeier, Dirk, Luo, Xiaoyu, Mangion, Kenneth   +5 more
core   +2 more sources

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Analytical and numerical analyses of the micromechanics of soft fibrous connective tissues

, 2012
State of the art research and treatment of biological tissues require accurate and efficient methods for describing their mechanical properties. Indeed, micromechanics motivated approaches provide a systematic method for elevating relevant data from the ...
A Menzel, AD Freed, AN Gent, D Ambrosi, D Balzani, DE Kiousis, G deBotton, G deBotton, G deBotton, G deBotton, G deBotton, G Shmuel, GA Holzapfel, GA Holzapfel, GA Holzapfel, GA Holzapfel, GA Holzapfel, GA Holzapfel, Gal deBotton, H Chen, I Hariton, I Hariton, J Humphrey, J Stålhand, JD Humphrey, JD Humphrey, JD Humphrey, JD Humphrey, JF Eberth, L Figueiredo Borges de, LA Taber, M Agoras, M Brun, N Gundiah, N Triantafyllidis, NC Avery, O Lopez-Pamies, P Mortier, P Ponte Castañeda, R Hill, RM Nerem, RW Ogden, S Rudykh, Tal Oren, V Alastrué, Y Lanir, YC Fung   +46 more
core   +1 more source

Mechanobiomaterials: Harnessing mechanobiology principles for tissue repair and regeneration

Mechanobiology in medicine
Mechanical stimuli are known to play critical roles in mediating tissue repair and regeneration. Recently, this knowledge has led to a paradigm shift toward proactive programming of biological functionalities of biomaterials by leveraging mechanics ...
Xiao Lin, Huan Yang, Yi Xia, Kang Wu, Fengcheng Chu, Huan Zhou, Huajian Gao, Lei Yang   +7 more
semanticscholar   +1 more source

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

Focal adhesions are controlled by microtubules through local contractility regulation

The EMBO Journal
Microtubules regulate cell polarity and migration via local activation of focal adhesion turnover, but the mechanism of this process is insufficiently understood.
Julien Aureille, Srinivas S Prabhu, Sam F Barnett, Aaron J Farrugia, Isabelle Arnal, Laurence Lafanechère, Boon Chuan Low, Pakorn Kanchanawong, Alex Mogilner, Alexander D Bershadsky   +9 more
doaj   +1 more source

Comment on "Orientational Distribution of Free O-H Groups of Interfacial Water is Exponential"

, 2019
In a recent letter (PRL,121,246101,2018), Sun et al. reported that combined MD simulation and sum frequency generation vibrational spectroscopy (SFG-VS) measurements led to conclusions of a broad and exponentially decaying orientational distribution, and
Feng, Ran-ran, Gan, Wei, Wang, Hong-Fei
core   +1 more source