Results 91 to 100 of about 35,268 (338)

On the generation of force required for actin-based motility

Scientific Reports
The fundamental question of how forces are generated in a motile cell, a lamellipodium, and a comet tail is the subject of this note. It is now well established that cellular motility results from the polymerization of actin, the most abundant protein in
Alberto Salvadori, Claudia Bonanno, Mattia Serpelloni, Robert M. McMeeking   +3 more
doaj   +1 more source

Mechanobiology in cellular, molecular, and tissue adaptation

Mechanobiology in medicine, 2023
The use of mechanical biology and biomechanical signal transduction is a novel approach to attenuate biological tissue degeneration, whereas the understanding of specific cellular responses is critical to delineate the underlying mechanism.
Yi-Xian Qin, Jie Zhao
semanticscholar   +1 more source

Stable, covalent attachment of laminin to microposts improves the contractility of mouse neonatal cardiomyocytes. [PDF]

, 2014
The mechanical output of contracting cardiomyocytes, the muscle cells of the heart, relates to healthy and disease states of the heart. Culturing cardiomyocytes on arrays of elastomeric microposts can enable inexpensive and high-throughput studies of ...
Ashley, Euan A, Pruitt, Beth L, Ribeiro, Alexandre JS, Zaleta-Rivera, Kathia   +3 more
core   +2 more sources

A Superhydrophobic 3D Cell Culture System Reveals the Mechanobiological Role of Cancer‐Associated Fibroblasts in Prostate Cancer Metastasis

Advanced Healthcare Materials, EarlyView.
A superhydrophobic 3D cell culture platform enables rapid and consistent formation of heterotypic tumor–stroma clusters, and reveals how physiological shear conditions influence metastatic signaling. Mechanical stimulation of cancer‐associated fibroblasts promotes sustained cytokine secretion and survival‐promoting pathways, showing how multicellular ...
Alexandria T. Carter, Abigail R. Fabiano, Ehsan Aalaei, Jason Deng, Dakota E. Rostant, Michael R. King   +5 more
wiley   +1 more source

Exploring the Dynamic Concept of Mechanobiology in Regenerative Rehabilitation: A Narrative Review [PDF]

Journal of Clinical and Diagnostic Research
Physical therapists, equipped with unique diagnostic and treatment capabilities, play a pivotal role in advancing regenerative medicine. The present review explores the integration of mechanotherapy and mechanical techniques in physiotherapy, shedding ...
Purva Gulrandhe, Sourya Acharya, Pratik Phansopkar, Waqar Naqvi   +3 more
doaj   +1 more source

Calcium mediated functional interplay between myocardial cells upon laser-induced single-cell injury: an in vitro study of cardiac cell death signaling mechanisms

Cell Communication and Signaling, 2020
Background The electromechanical function of myocardial tissue depends on the intercellular communication between cardiomyocytes (CMs) as well as their crosstalk with other cell types.
Krishna Chander Sridhar, Nils Hersch, Georg Dreissen, Rudolf Merkel, Bernd Hoffmann   +4 more
doaj   +1 more source

Modeling Receptor Motility along Advecting Lipid Membranes

Membranes, 2022
This work aims to overview multiphysics mechanobiological computational models for receptor dynamics along advecting cell membranes. Continuum and statistical models of receptor motility are the two main modeling methodologies identified in reviewing the
Matteo Arricca, Alberto Salvadori, Claudia Bonanno, Mattia Serpelloni   +3 more
doaj   +1 more source

Acoustic Tweezing Cytometry Induces Rapid Initiation of Human Embryonic Stem Cell Differentiation. [PDF]

, 2018
Mechanical forces play critical roles in influencing human embryonic stem cell (hESC) fate. However, it remains largely uncharacterized how local mechanical forces influence hESC behavior in vitro.
Deng, Cheri X, Fan, Zhenzhen, Fu, Jianping, Hong, Xiaowei, Kanetkar, Ninad, Krebsbach, Paul H, Nguyen, Joe T, Topal, Tuğba, Xue, Xufeng   +8 more
core   +2 more sources

From gene to mechanics: a comprehensive insight into the mechanobiology of LMNA mutations in cardiomyopathy

Cell Communication and Signaling
Severe cardiac remodeling leading to heart failure in individuals harboring pathogenic LMNA variants, known as cardiolaminopathy, poses a significant clinical challenge. Currently, there is no effective treatment for lamin-related diseases. Exploring the
R. J. A. Veltrop, M. M. Kukk, K. Topouzidou, L. Didden, A. Muchir, F. V. van Steenbeek, L. J. Schurgers, M. Harakalova   +7 more
semanticscholar   +1 more source

Mechanobiology in oncology: basic concepts and clinical prospects

Frontiers in Cell and Developmental Biology, 2023
The interplay between genetic transformations, biochemical communications, and physical interactions is crucial in cancer progression. Metastasis, a leading cause of cancer-related deaths, involves a series of steps, including invasion, intravasation ...
Michelle B. Chen, Yousef Javanmardi, Somayeh Shahreza, Bianca Serwinski, A. Aref, Boris Djordjevic, E. Moeendarbary   +6 more
semanticscholar   +1 more source