Results 91 to 100 of about 18,551 (276)
Focal adhesions are controlled by microtubules through local contractility regulation
The EMBO JournalMicrotubules regulate cell polarity and migration via local activation of focal adhesion turnover, but the mechanism of this process is insufficiently understood.
Julien Aureille +9 more
doaj +1 more source
Cell motion and mechanobiology
Molecular Biology of the Cell, 2015 Diverse new and stimulating results at the interfaces between cell and molecular biology and biophysics were presented in this session cochaired by Ewa Paluch (University College London) and Dennis Discher (University of Pennsylvania). A number of physical features of the cell and its microenvironment were shown to impact the functions and fates of ...
Paluch, Ewa K., Discher, Dennis E.
openaire +2 more sources
Advanced Science, EarlyView.This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu +10 more
wiley +1 more source
Advanced Science, EarlyView.A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li +9 more
wiley +1 more source
Advanced Science, EarlyView.An enzyme–nitric oxide (NO) co‐regulatory strategy reprograms pathological extracellular matrix (ECM)–fibroblast crosstalk in hypertrophic scars. Enzymatic degradation of pre‐existing ECM relieves aberrant mechanical cues, while NO‐mediated fibroblast phenotypic modulation restrains excessive collagen synthesis.
Junzhe Fu +7 more
wiley +1 more source
FREQUENCY AND AMPLITUDE CONTROL OF CORTICAL OSCILLATIONS BY LIPID METABOLISM
, 2016 Ph.DPH.D.
XIONG DING
core
CYCLICAL REGULATION OF A CONTRACTILE TUBE: INSIGHTS FROM THE CAENORHABDITIS ELEGANS SPERMATHECA [PDF]
, 2015 Ph.DPH.D.
TAN PEI YI
core
Advanced Science, EarlyView.Matrix stiffness directs mesenchymal stem cell lineage commitment through PIEZO1‐dependent activation of the SP1/STC2 pathway. Stiff matrices favor osteogenesis and suppress adipogenesis, whereas the loss of PIEZO1 function impairs early bone formation. STC2 retains lineage‐regulatory activity even when PIEZO1 is inactive.
Shuo Zhang +12 more
wiley +1 more source
CELL GEOMETRIC CONSTRAINTS REGULATE NUCLEAR AND CHROMATIN PLASTICITY VIA ACTOMYOSIN CONTRACTILITY [PDF]
, 2015 Ph.DPH.D.
EKTA MAKHIJA
core